ArticleInternational journal of preventive medicine2014
Association of Human Papilloma Virus 16 Infection and p53 Polymorphism among Tobacco using Oral Leukoplakia Patients: A Clinicopathologic and Genotypic Study.
Article in International journal of preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic evaluation of TP53 codon 72 polymorphism associated with onset and progression of oral potentially malignant disorders.BMC oral health · 2023Pooled it
- Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis.BMC oral health · 2018Pooled it
- Viral Involvement in Oral Potentially Malignant Disorders: A Scoping Review.Cancer management and research · 2025Review
- Genetic polymorphism of tumor necrosis factor alpha (TNF-α) and tumor necrosis factor beta (TNF-β) genes and risk of oral pre-cancer and cancer in North Indian population.Oral and maxillofacial surgery · 2022Article
- High Prevalence of Human Papillomavirus Type 18 in Oral Potentially Malignant Disorders in Thailand.Asian Pacific journal of cancer prevention : APJCP · 2021Article
- Detection of HPV in oral leukoplakia by brushing and biopsy: prospective study in an Italian cohort.Clinical oral investigations · 2020Article
- Major Molecular Signaling Pathways in Oral Cancer Associated With Therapeutic Resistance.Frontiers in oral health · 2020Review
- TP53 single nucleotide polymorphism (rs1042522) in Iranian patients with coronary artery disease.Biomedical reports · 2018Article
- Single nucleotide polymorphisms as markers of genetic susceptibility for oral potentially malignant disorders risk: Review of evidence to date.Oral oncology · 2016Review
- Expression of Human Papillomavirus DNA and p53 Polymorphisms through Polymerase Chain Reaction in Normal Mucosa and Oral Leukoplakia Individuals with Deleterious Oral Habits.International journal of applied & basic medical researchArticle
- Role of human papillomavirus in oral squamous cell carcinoma and oral potentially malignant disorders: A review of the literature.Indian journal of dentistryReview
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
backgroundHuman papillomavirus (HPV) and p53 alterations are speculated to play a role in carcinogenesis. This study was carried out to find out the association of HPV and p53 with precancerous lesions of the oral cavity such as leukoplakia: The objective of this study was to find the association among human papilloma virus (HPV) 16 infections and p53 polymorphism in tobacco using the oral leukoplakia patients.
methodsA total of 91 oral leukoplakia patients and 100 controls were randomly selected from the out-patient department of a tertiary care dental hospital of North-east India. Blood samples were drawn incisional biopsy was performed from the lesion proper and the tissue was processed for histopathological grading. Cytological smears were taken from the lesional site of leukoplakia patients and buccal mucosa of controls. The rate of HPV infection and p53 polymorphism was detected with the help of polymerase chain reaction, gel electrophoresis and deoxyribonucleic acid sequencing.
resultsThe rate of HPV 16 infection was found significantly high in the oral leukoplakia patients. No particular p53 genotype at exon 4 of codon 72 was found to be associated with oral leukoplakia, but "C" allele (proline) at exon 4 of codon 72 was significantly raised in these patients.
conclusionsOral leukoplakia, a well-known pre-cancerous lesion, has been shown to be associated with tobacco, but certain other factors like HPV infection and p53 polymorphism may play an important role in its development.
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24829730PMC4018591What OpenQuestion holds
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