ArticleInternational journal of preventive medicine2014
Does naloxone prevent seizure in tramadol intoxicated patients?
Article in International journal of preventive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Harmful Effects of Prescribed Opioids in Children and Adults: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Zinc oxide calcium silicate composite attenuates acute tramadol toxicity in mice.BMC pharmacology & toxicology · 2023Article
- Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat.Pharmaceuticals (Basel, Switzerland) · 2022Article
- The effects of quercetin on seizure, inflammation parameters and oxidative stress in acute on chronic tramadol intoxication.BMC pharmacology & toxicology · 2021Article
- Effects of naloxone and diazepam on blood glucose levels in tramadol overdose using generalized estimating equation (GEE) model; (an experimental study).BMC endocrine disorders · 2021Article
- The effects of naloxone, diazepam, and quercetin on seizure and sedation in acute on chronic tramadol administration: an experimental study.Behavioral and brain functions : BBF · 2021Article
- Risk of Seizure after Naloxone Therapy in Acute Tramadol Poisoning: A Systematic Review with Meta-Analysis.International journal of preventive medicine · 2019Article
- Acute tramadol poisoning and its clinical and laboratory findings.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Common Opioids Involved in Drug Poisoning Presenting to the Emergency Department: A Cross-sectional Study.Journal of research in pharmacy practiceArticle
- Acute Tramadol-Induced Cellular Tolerance and Dependence of Ventral Tegmental Area Dopaminergic Neurons: An In Vivo Electrophysiological Study.Basic and clinical neuroscienceArticle
- Hypoglycemia in a Child with Tramadol Poisoning.Saudi journal of medicine & medical sciencesArticle
- Author's Reply.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTramadol poisoning has increased in recent years. Seizure is one of the side-effects of tramadol toxicity. There is a controversy about possible preventive effect of naloxone in tramadol poisoning induced seizure. Therefore, this study was performed to compare seizure incidence in tramadol poisoning patients who received and did not receive naloxone, as an opioid antagonist.
methodsThis study involved prospective data collection followed by retrospective analysis on 104 tramadol poisoning patients who were admitted in a referral poisoning center. The incidences of seizure were compared between patients received naloxone and those did not. Outcome was considered as survived without or with complications and death. Logistic Regression analysis was used to determine the effects of different variables on seizure incidence.
results70 (67.3%) of the patients were men. The mean age of the patients was 26.3 ± 9 years old. 18.3% of the patients received naloxone in their treatment period. Seizure incidence was significantly higher among tramadol poisoning patients who did not receive naloxone compare with those received naloxone (14.1% vs. 5.1%). Among different variable studied, age had a significant effect on predicting of seizure (odds ratio = 2.09; 95% of confidence interval: 1.82-2.26; P value, 0.004).
conclusionsAlthough the seizure incidence was lower in patients with tramadol poisoning who received naloxone, the logistic regression did not support the preventive effect of naloxone on seizure in tramadol poisoning cases.
Indexed as
Identifiers
24829714PMC4018639W1509796435What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.