Evidence map›Paper›PMID 24829676›Full record

ArticleMiddle East journal of digestive diseases2013

Diagnostic Value of ASCA and Atypical p-ANCA in Differential Diagnosis of Inflammatory Bowel Disease.

Ali Mokhtarifar, Azita Ganji, Mohsen Sadrneshin, Ali Bahari, Abbas Esmaeilzadeh, Kamran Ghafarzadegan, Shafagh Nikpour

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In one paragraph

Article in Middle East journal of digestive diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. ANCA and ASCA Profiles in a Moroccan Population With Inflammatory Bowel Diseases.Journal of community hospital internal medicine perspectives · 2024
    Article
  7. Review
  8. Inflammatory bowel disease biomarkers.Medicinal research reviews · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ali MokhtarifarDepartment of Gastroenterology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Azita GanjiDepartment of Gastroenterology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohsen SadrneshinResearch Center for Gastroenterology and Liver Diseases, Mashhad University of Medical Sciences, Mashhad, Iran.
Ali BahariDepartment of Gastroenterology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Abbas EsmaeilzadehDepartment of Gastroenterology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Kamran GhafarzadeganRazavi Hospital, Mashhad, Iran.
Shafagh NikpourResearch Center for Gastroenterology and Liver Diseases, Mashhad University of Medical Sciences, Mashhad, Iran.
Imam Reza Hospital · IREmam Reza Hospital · IRMashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWorldwide, the incidence of inflammatory bowel disease (IBD) is increasing. This study aims to evaluate the diagnostic value of two serological markers, atypical perinuclear anti-neutrophil cytoplasmic antibodies (atypical-P-ANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA), with the intent to determinetheir relationship to ulcerative colitis (UC) and Crohn's disease (CD), in addition to the location and extent of bowel involvement.

methodsThere were 97 patients enrolled in this study, 72 diagnosed with UC and 25 with CD.The control group consisted of 40 healthy individuals. ASCA was determined by enzyme-linked immunosorbent assay (ELISA) and atypical-P-ANCA by indirect immunofluorescence assay (IIF). For data analyses, we used the chi-square and independent t-tests. Significance was considered to be p<0.05.

resultsFor CD, the sensitivityof ASCA was 16% and its specificity was 97%.ASCA had a specifity of 90% in UC patients. The atypical P-ANCA test had a sensitivity of 44% and specificity of 86% for UC. The positive predictive value (PPV) for atypical P-ANCA in UC patients was 78% and for the negative predictive value (NPV), it was 58%.There was no correlation between ASCA and atypical P-ANCA results and the location of gastrointestinal (GI) involvement in CD (p=0.61) and UC (p=0.28) patients.

conclusionAccording to the results, ASCA and atypical P-ANCA markers are not useful for IBD screening. Our study suggests that atypical P-ANCA is a useful parameter to differentiate UC from CD. However, ASCA is of limited value for screening and differentiating UC from CD.

Indexed as

Anti-Saccharomyces cerevisiae antibodyAtypical perinuclear anti-neutrophil cytoplasmic antibodyInflammatory bowel disease

Identifiers

PMID24829676
PMCPMC3990141
OpenAlexW2143099730

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.