ArticleMiddle East journal of digestive diseases2013
Diagnostic value of fecal calprotectin in patient with ulcerative colitis.
Article in Middle East journal of digestive diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association of TMAO levels with indicators of ulcerative colitis activity.Caspian journal of internal medicine · 2025Article
- Intraperitoneal Administration of S100A8 Ameliorates Experimental Acute Colitis in Rats.Biology · 2024Article
- Article
- Circulating S100A8/A9 is potentially a biomarker that could reflect the severity of experimental colitis in rats.Heliyon · 2020Article
- Investigation of inflammatory bowel disease risk factors in 4 families in central China.Experimental and therapeutic medicine · 2018Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundUlcerative colitis (UC) is characterized by recurrent episodes of inflammation limited to the mucosal layer of the colon. Calprotectin is a zinc and calcium binding protein derived from neutrophils and monocytes. It is easily detectable in tissue samples, body fluids, and stools, which makes it a potentially valuable marker of inflammation. The aim of the current study is to evaluate the value of fecal calprotectin (FC) as a marker of disease activity in patients with UC.
methodsSeventy three eligible subjects underwent ileocolonoscopy and multiple biopsies were obtained from different parts of the colon and terminal ileum. All patients underwent blood and stool sampling as well as an interview to assess the disease severity utilizing ulcerative colitis activity index (UCAI), subjectively. The diagnostic value of the FC in comparison with Mayo disease activity index as the gold standard technique, was then evaluated.
resultsMean FC level increased linearly according to Mayo disease activity index (r=0.44, p<0.001) and was significantly different between levels of Mayo disease activity index (p=0.003). In multivariate analysis, Mayo disease activity index, positive CRP and ESR were associated with FC level. FC level > 21.4 ng/ml was able to discriminate between active and inactive phases of UC according to Mayo disease activity index>2 with 72.3% sensitivity and 73.1% specificity. The combination of FC > 21.4 ng/ml and UCAI score of 7 had a 46.8% sensitivity and 88% specificity to diagnose Mayo disease activity index >2. Furthermore, FC level <21.4 ng/ml in combination with UCAI score of <3 showed a highly considerable specificity of 98% to discriminate the remission phase of UC (Mayo disease activity index <2), although with a low sensitivity (31%).
conclusionFC appears to be a non-invasive biomarker with moderate accuracy to discriminate the active phase of inflammatory bowel disease (IBD). The value of FC especially in combination with UCAI is highly considerable to rule out the Mayo disease activity index >2.
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24829673PMC3990145What OpenQuestion holds
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