ArticleGastroenterology research and practice2014
Lactose malabsorption testing in daily clinical practice: a critical retrospective analysis and comparison of the hydrogen/methane breath test and genetic test (c/t-13910 polymorphism) results.
Article in Gastroenterology research and practice, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Antibiotic therapy for small intestinal bacterial overgrowth: a systematic review of comparative efficacy, clinical-test discordance, and pediatric evidence gaps.Frontiers in pharmacology · 2026Pooled it
- Hydrogen and Methane Breath Test: The Asian Neurogastroenterology and Motility Association Monograph.Journal of neurogastroenterology and motility · 2026Review
- Progress and challenges of developing volatile metabolites from exhaled breath as a biomarker platform.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Identification of SIBO Subtypes along with Nutritional Status and Diet as Key Elements of SIBO Therapy.International journal of molecular sciences · 2024Observational
- Article
- Lactase Deficiency Diagnosed by Endoscopic Biopsy-based Method is Associated With Positivity to Glucose Breath Test.Journal of neurogastroenterology and motility · 2023Article
- Induced volatolomics of pathologies.Nature reviews. Chemistry · 2021Review
- Clinical Utility ofNutrients · 2020Observational
- Nutritional management of lactose intolerance: the importance of diet and food labelling.Journal of translational medicine · 2020Review
- Sex-Specific Associations of Trimethylamine-N-Oxide and Zonulin with Signs of Depression in Carbohydrate Malabsorbers and Nonmalabsorbers.Disease markers · 2020Article
- Congruency of Genetic Predisposition to Lactase Persistence and Lactose Breath Test.Nutrients · 2019Article
- 13910C>T and 22018G>AUnited European gastroenterology journal · 2019Article
- Non-celiac gluten sensitivity: people without celiac disease avoiding gluten-is it due to histamine intolerance?Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2018Review
- Association between increased plasma levels of homocysteine and depression observed in individuals with primary lactose malabsorption.PloS one · 2018Article
- Retrospective analysis of a lactose breath test in a gastrointestinal symptomatic population of Northeast Italy: use of (HClinical and experimental gastroenterology · 2018Article
- Assessment of vitamin D status and serum CrossLaps levels in adults with primary lactose malabsorption.European journal of clinical nutrition · 2016Article
- Refining small intestinal bacterial overgrowth diagnosis by means of carbohydrate specificity: a proof-of-concept study.Therapeutic advances in gastroenterology · 2016Article
- Concomitant Prevalence of Low Serum Diamine Oxidase Activity and Carbohydrate Malabsorption.Canadian journal of gastroenterology & hepatology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to establish a retrospective evaluation and comparison of the hydrogen/methane (H2/CH4) breath test and genetic test (C/T-13910 polymorphism) results in lactose malabsorption testing. In total 263 consecutive patients with suspected lactose malabsorption were included in this study. They underwent the H2/CH4 breath test following the ingestion of 50 g lactose and were tested for the C/T-13910 polymorphism. In total 51 patients (19.4%) had a C/C-13910 genotype, indicating primary lactose malabsorption. Only 19 patients (7.2%) also had a positive H2/CH4 breath test. All in all 136 patients (51.69%) had a C/T-13910 and 76 patients (28.91%) a T/T-13910 genotype, indicating lactase persistence. Four patients (1.5%) with the C/T-13910 genotype and one patient (0.4%) with the T/T-13910 genotype had a positive H2/CH4 breath test result, indicating secondary lactose malabsorption. Cohen's Kappa measuring agreement between the two methods was 0.44. Twenty patients (7.6%) with a positive H2/CH4 peak within 60 minutes after lactose ingestion were classified as patients with lactose-dependent small intestinal bacterial overgrowth (SIBO). In conclusion, only moderate agreement between the breath test and the genetic test was shown. Secondary lactose malabsorption as well as preanalytical limitations of the combined H2/CH4 breath test procedure can cause discrepant results. This trial is registered with K-42-13.
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Registered trials
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