ReviewFrontiers in endocrinology2014
Measurement of androgen and estrogen concentrations in cord blood: accuracy, biological interpretation, and applications to understanding human behavioral development.
Review in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children.PloS one · 2015Trial
- Sex Steroid Hormone Signaling Tunes Metabolic and Neuronal Programs in Human Cortical Development.Research square · 2026Article
- Revisiting the dual role of androgens and oestrogens in mammalian sex differentiation with a focus on genitalia.Nature reviews. Urology · 2026Review
- Prenatal exposure to perfluoroalkyl sulfonic and carboxylic acids and neurodevelopmental delay in children up to 5 years old: Effect modification by progesterone and estradiol.Eco-Environment & Health · 2026Article
- Androgen and estrogen secretory dynamics in longitudinally followed moderately and late preterm infant girls.Journal of the Endocrine Society · 2026Article
- Hormonal imbalance in umbilical vein cord blood of pregnant women with endometriosis: a propensity score-matched analysis.Reproductive biology and endocrinology : RB&E · 2025Article
- Longitudinal Relationship of Early Postnatal Testosterone and Harsh Parenting at 1-3 Months of Age to Physical Aggression at 12 Months of Age in Boys and Girls.Biological psychiatry global open science · 2025Article
- Associations of per- and polyfluoroalkyl substances with maternal early second trimester sex-steroid hormones.International journal of hygiene and environmental health · 2024Article
- Prenatal Exposure to PFAS, Associations with Preterm Birth and Modification by Maternal Estrogen Levels: The Maoming Birth Study.Environmental health perspectives · 2023Article
- Article
- The association of prenatal amniotic sex hormones and digit ratio (2D:4D) in children aged 5 to 70 months: A longitudinal study.PloS one · 2023Article
- Article
- Sex-related external factors influence pulmonary vascular angiogenesis in a sex-dependent manner.American journal of physiology. Heart and circulatory physiology · 2023Article
- Longitudinal Sex Steroid Data in Relation to Birth Weight in Preterm Boys.The Journal of clinical endocrinology and metabolism · 2022Article
- Digit ratio (2D:4D) and maternal testosterone-to-estradiol ratio measured in early pregnancy.Scientific reports · 2022Article
- Gestational Exposure to Phthalates and Social Responsiveness Scores in Children Using Quantile Regression: The EARLI and HOME Studies.International journal of environmental research and public health · 2021Article
- Do sex hormones at birth predict later-life economic preferences? Evidence from a pregnancy birth cohort study.Proceedings. Biological sciences · 2020Article
- Urine Metabolome during Parturition.Metabolites · 2020Article
- Androgen and Anti-Mullerian Hormone Concentrations at Term in Newborns and Their Mothers with and without Polycystic Ovary Syndrome.Journal of clinical medicine · 2019Article
- Hyperandrogenic origins of polycystic ovary syndrome - implications for pathophysiology and therapy.Expert review of endocrinology & metabolism · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accurately measuring hormone exposure during prenatal life presents a methodological challenge and there is currently no "gold standard" approach. Ideally, circulating fetal hormone levels would be measured at repeated time points during pregnancy. However, it is not currently possible to obtain fetal blood samples without significant risk to the fetus, and therefore surrogate markers of fetal hormone levels must be utilized. Umbilical cord blood can be readily obtained at birth and largely reflects fetal circulation in late gestation. This review examines the accuracy and biological interpretation of the measurement of androgens and estrogens in cord blood. The use of cord blood hormones to understand and investigate human development is then discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.