Trial reportAmerican journal of physiology. Regulatory, integrative and comparative physiology2014
Mindfulness meditation lowers muscle sympathetic nerve activity and blood pressure in African-American males with chronic kidney disease.
Trial report in American journal of physiology. Regulatory, integrative and comparative physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Meditation and Cardiovascular Risk Reduction: A Scientific Statement From the American Heart Association.Journal of the American Heart Association · 2017Guideline
- Impacts of mindfulness-based interventions in people undergoing hemodialysis: a systematic review.Jornal brasileiro de nefrologiaPooled it
- Autonomic modulation with mindfulness-based stress reduction in chronic kidney disease: a randomized controlled trial.The Journal of physiology · 2025Trial
- The influence of mindfulness meditation combined with progressive muscle relaxation training on the clinical efficacy and quality of life of patients with sarcopenia receiving haemodialysis: a randomised controlled trial.BMC complementary medicine and therapies · 2024Trial
- Slower respiration rate is associated with higher self-reported well-being after wellness training.Scientific reports · 2023Trial
- Heart Rate Variability Moderates the Association Between Trait Anxiety and Sympathetic Nerve Activity in Humans.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Contemplative Practices as a Form of Stress Management for Patients with Kidney Disease.Clinical journal of the American Society of Nephrology : CJASN · 2025Review
- Greater negative affective responsivity to daily stressors is positively related to urinary norepinephrine excretion in middle-aged adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Autonomic Modulation with Mindfulness-Based Stress Reduction in Chronic Kidney Disease: A Randomized Controlled Trial.medRxiv : the preprint server for health sciences · 2024Article
- Review
- Heat of the night: sleep disturbance activates inflammatory mechanisms and induces pain in rheumatoid arthritis.Nature reviews. Rheumatology · 2023Review
- Interventions to support decision-making, health literacy and self-management in ethnic-minority adults living with chronic kidney disease: a systematic review.Clinical kidney journal · 2023Review
- Sleep disruption induces activation of inflammation and heightens risk for infectious disease: Role of impairments in thermoregulation and elevated ambient temperature.Temperature (Austin, Tex.) · 2023Article
- Effects of Meditation on Cardiovascular and Muscular Responses in Patients during Cardiac Rehabilitation: A Randomized Pilot Study.Journal of clinical medicine · 2022Article
- Temporomandibular Myofascial Pain Syndrome-Aetiology and Biopsychosocial Modulation. A Narrative Review.International journal of environmental research and public health · 2021Review
- Lifestyle interventions for the prevention and treatment of hypertension.Nature reviews. Cardiology · 2021Review
- Interventions and Manipulations of Interoception.Trends in neurosciences · 2021Review
- Promoting Mindfulness in African American Communities.Mindfulness · 2020Article
- Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine-Induced Vasoconstriction in Young Adults.Journal of the American Heart Association · 2020Article
- Neural control of cardiovascular function in black adults: implications for racial differences in autonomic regulation.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Mindfulness meditation (MM) is a stress-reduction technique that may have real biological effects on hemodynamics but has never previously been tested in chronic kidney disease (CKD) patients. In addition, the mechanisms underlying the potential blood pressure (BP)-lowering effects of MM are unknown. We sought to determine whether MM acutely lowers BP in CKD patients, and whether these hemodynamic changes are mediated by a reduction in sympathetic nerve activity. In 15 hypertensive African-American (AA) males with CKD, we conducted a randomized, crossover study in which participants underwent 14 min of MM or 14 min of BP education (control intervention) during two separate random-order study visits. Muscle sympathetic nerve activity (MSNA), beat-to-beat arterial BP, heart rate (HR), and respiratory rate (RR) were continuously measured at baseline and during each intervention. A subset had a third study visit to undergo controlled breathing (CB) to determine whether a reduction in RR alone was sufficient in exacting hemodynamic changes. We observed a significantly greater reduction in systolic BP, diastolic BP, mean arterial pressure, and HR, as well as a significantly greater reduction in MSNA, during MM compared with the control intervention. Participants had a significantly lower RR during MM; however, in contrast to MM, CB alone did not reduce BP, HR, or MSNA. MM acutely lowers BP and HR in AA males with hypertensive CKD, and these hemodynamic effects may be mediated by a reduction in sympathetic nerve activity. RR is significantly lower during MM, but CB alone without concomitant meditation does not acutely alter hemodynamics or sympathetic activity in CKD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.