Evidence map›Paper›PMID 24829485›Full record

ReviewAdvances in nutrition (Bethesda, Md.)2014

Mediterranean diet and cardiovascular health: Teachings of the PREDIMED study.

Emilio Ros, Miguel A Martínez-González, Ramon Estruch, Jordi Salas-Salvadó, Montserrat Fitó, José A Martínez, Dolores Corella

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in nutrition (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03392025 (Effects of Flaxseed Consumption, Alone and in Combination With the Mediterranean-like Diet, on Vascular Endothelial Function and Some Biochemical Indicators Related to Atherosclerosis in Patients With Coronary Artery Disease), which is not on this map. Cited by 170 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
170citing papers in PubMed, 8 pooled it
26.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03392025 nacompletednot on this mapstarted 2017, after this paper: background citation

Effects of Flaxseed Consumption, Alone and in Combination With the Mediterranean-like Diet, on Vascular Endothelial Function and Some Biochemical Indicators Related to Atherosclerosis in Patients With Coronary Artery Disease

TypeinterventionalSponsorJavad NasrollahzadehRan2017 to 2018Enrolled87ConditionsCoronary Artery DiseaseArmsFlaxseed, the Mediterranean-like diet, Placebo
3 · Its place in the literature

Who cites it

170 citing papers in PubMed, 8 syntheses or guidelines pooled it, 384 citations in OpenAlex.

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110 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Emilio RosLipid Clinic, Endocrinology and Nutrition Service and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spanish Government, Spain; Departments of eros@clinic.ub.es.
Miguel A Martínez-GonzálezCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spanish Government, Spain; Departments of Preventive Medicine and Public Health and.
Ramon EstruchDepartment of Internal Medicine, Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spanish Government, Spain; Departments of.
Jordi Salas-SalvadóCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spanish Government, Spain; Departments of Human Nutrition Department, Sant Joan University Hospital, Pere Virgili Health Research Institute, Rovira i Virgili University, Reus, Spain.
Montserrat FitóCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spanish Government, Spain; Departments of Cardiovascular and Nutrition Research Group and Regicor Study Group, Hospital del Mar Research Institute, Barcelona, Spain; and.
José A MartínezCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spanish Government, Spain; Departments of Nutrition and Food Sciences, Physiology, and Toxicology, University of Navarra, Pamplona, Spain.
Dolores CorellaCIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Spanish Government, Spain; Departments of Department of Preventive Medicine, University of Valencia, Valencia, Spain.
Instituto de Salud Carlos III · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The PREDIMED (Prevención con Dieta Mediterránea) study was designed to assess the long-term effects of the Mediterranean diet (MeDiet) without any energy restriction on incident cardiovascular disease (CVD) as a multicenter, randomized, primary prevention trial in individuals at high risk. Participants were randomly assigned to 3 diet groups: 1) MeDiet supplemented with extra-virgin olive oil (EVOO); 2) MeDiet supplemented with nuts; and 3) control diet (advice on a low-fat diet). After 4.8 y, 288 major CVD events occurred in 7447 participants; crude hazard ratios were 0.70 (95% CI: 0.53, 0.91) for the MeDiet + EVOO and 0.70 (95% CI: 0.53, 0.94) for the MeDiet + nuts compared with the control group. Respective hazard ratios for incident diabetes (273 cases) among 3541 participants without diabetes were 0.60 (95% CI: 0.43, 0.85) and 0.82 (95% CI: 0.61, 1.10) compared with the control group. After 1-y follow-up, participants in the MeDiet + nuts group showed a significant 13.7% reduction in prevalence of metabolic syndrome compared with reductions of 6.7% and 2.0% in the MeDiet + EVOO and control groups, respectively. Analyses of intermediate markers of cardiovascular risk demonstrated beneficial effects of the MeDiets on blood pressure, lipid profiles, lipoprotein particles, inflammation, oxidative stress, and carotid atherosclerosis, as well as on the expression of proatherogenic genes involved in vascular events and thrombosis. Nutritional genomics studies demonstrated interactions between a MeDiet and cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), apolipoprotein A2 (APOA2), cholesteryl ester transfer protein plasma (CETP), and transcription factor 7-like 2 (TCF7L2) gene polymorphisms. The PREDIMED study results demonstrate that a high-unsaturated fat and antioxidant-rich dietary pattern such as the MeDiet is a useful tool in the prevention of CVD.

Indexed as

Diet, MediterraneanAgedAged, 80 and overBiomarkersCardiovascular DiseasesCardiovascular SystemDiet, Fat-RestrictedFemaleHumansMaleMeta-Analysis as TopicMetabolic SyndromeMiddle AgedNutrigenomicsNutsObservational Studies as TopicBiomarkersOlive OilPlant Oils

Identifiers

PMID24829485
PMCPMC4013190
OpenAlexW2101940313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.