Evidence map›Paper›PMID 24829458›Full record

ArticleNucleic acids research2014

RBPmap: a web server for mapping binding sites of RNA-binding proteins.

Inbal Paz, Idit Kosti, Manuel Ares, Melissa Cline, Yael Mandel-Gutfreund

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 369 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
369citing papers in PubMed, 1 pooled it
9.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

369 citing papers in PubMed, 1 synthesis or guideline pooled it, 614 citations in OpenAlex.

  1. Pooled it
  2. NAR cancer · 2026
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309 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Inbal PazDepartment of Biology, Technion - Israel Institute of Technology, Technion City, Haifa 32000, Israel.
Idit KostiDepartment of Biology, Technion - Israel Institute of Technology, Technion City, Haifa 32000, Israel.
Manuel AresDepartment of Molecular, Cellular and Developmental Biology, UCSC, Santa Cruz, CA, USA.
Melissa ClineCenter for Biomolecular Science & Engineering, UCSC, Santa Cruz, CA, USA.
Yael Mandel-GutfreundDepartment of Biology, Technion - Israel Institute of Technology, Technion City, Haifa 32000, Israel yaelmg@tx.technion.ac.il.
Technion – Israel Institute of Technology · ILUniversity of California, Santa Cruz · US

Funding

STRUCTURE/FUNCTION OF YEAST SMALL NUCLEAR RNPSR01GM040478 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ARES, MANUEL · 1988 to 2021
$10.8M
NIGMS NIH HHS R01 GM040478
6 · The paper itself

Abstract

Regulation of gene expression is executed in many cases by RNA-binding proteins (RBPs) that bind to mRNAs as well as to non-coding RNAs. RBPs recognize their RNA target via specific binding sites on the RNA. Predicting the binding sites of RBPs is known to be a major challenge. We present a new webserver, RBPmap, freely accessible through the website http://rbpmap.technion.ac.il/ for accurate prediction and mapping of RBP binding sites. RBPmap has been developed specifically for mapping RBPs in human, mouse and Drosophila melanogaster genomes, though it supports other organisms too. RBPmap enables the users to select motifs from a large database of experimentally defined motifs. In addition, users can provide any motif of interest, given as either a consensus or a PSSM. The algorithm for mapping the motifs is based on a Weighted-Rank approach, which considers the clustering propensity of the binding sites and the overall tendency of regulatory regions to be conserved. In addition, RBPmap incorporates a position-specific background model, designed uniquely for different genomic regions, such as splice sites, 5' and 3' UTRs, non-coding RNA and intergenic regions. RBPmap was tested on high-throughput RNA-binding experiments and was proved to be highly accurate.

Indexed as

SoftwareAlgorithmsAnimalsBinding SitesDrosophila melanogasterHumansInternetMiceNucleotide MotifsRNARNA-Binding ProteinsSequence Analysis, RNARNARNA-Binding Proteins

Identifiers

PMID24829458
PMCPMC4086114
OpenAlexW2122358139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.