ArticleJournal of immunology (Baltimore, Md. : 1950)2014
Targeting antigens through blood dendritic cell antigen 2 on plasmacytoid dendritic cells promotes immunologic tolerance.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Recombinant Antibody Vaccines for Targeted Antigen Delivery: Design Principles and Immunological Applications.Vaccines · 2026Review
- Modulation of Human Dendritic Cell Functions by Phosphodiesterase-4 Inhibitors: Potential Relevance for the Treatment of Respiratory Diseases.Pharmaceutics · 2023Review
- Review
- Emerging glyco-based strategies to steer immune responses.The FEBS journal · 2021Review
- Plasmacytoid dendritic cell biology and its role in immune-mediated diseases.Clinical & translational immunology · 2020Review
- Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Profiling dendritic cell subsets in head and neck squamous cell tonsillar cancer and benign tonsils.Scientific reports · 2018Article
- Dendritic Cells As Inducers of Peripheral Tolerance.Trends in immunology · 2017Review
- FOXP3-Positive Regulatory T Cells and Kidney Allograft Tolerance.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2017Review
- Plasmacytoid dendritic cell distribution and maturation are altered in lupus prone mice prior to the onset of clinical disease.Clinical immunology (Orlando, Fla.) · 2017Article
- Review
- Reduced Dendritic Cells Expressing CD200R1 in Children with Inflammatory Bowel Disease: Correlation with Th17 and Regulatory T Cells.International journal of molecular sciences · 2015Article
- Human dendritic cell subsets and function in health and disease.Cellular and molecular life sciences : CMLS · 2015Review
- Cellular and molecular targeting for nanotherapeutics in transplantation tolerance.Clinical immunology (Orlando, Fla.) · 2015Review
- The multifaceted biology of plasmacytoid dendritic cells.Nature reviews. Immunology · 2015Review
- Targeting C-Type Lectin Receptors for Cancer Immunity.Frontiers in immunology · 2015Review
- Role of Dendritic Cells in the Induction of Lymphocyte Tolerance.Frontiers in immunology · 2015Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The C-type lectin receptor blood dendritic cell Ag 2 (BDCA2) is expressed exclusively on human plasmacytoid DCs (pDCs) and plays a role in Ag capture, internalization, and presentation to T cells. We used transgenic mice that express human BDCA2 and anti-BDCA2 mAbs to deliver Ags directly to BDCA2 on pDCs in vivo. Targeting Ag to pDCs in this manner resulted in significant suppression of Ag-specific CD4(+) T cell and Ab responses upon secondary exposure to Ag in the presence of adjuvant. Suppression of Ab responses required both a decrease in effector CD4(+) T cells and preservation of Foxp3(+) regulatory T cells (Tregs). Reduction in Treg numbers following Ag delivery to BDCA2 restored both CD4(+) T cell activation and Ab responses, demonstrating that Tregs were required for the observed tolerance. Our results demonstrate that Ag delivery to pDCs through BDCA2 is an effective method to induce immunological tolerance, which may be useful for treating autoimmune diseases or to inhibit unwanted Ab responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.