ArticleJournal of immunology (Baltimore, Md. : 1950)2014
The longevity of memory CD8 T cell responses after repetitive antigen stimulations.
Article in Journal of immunology (Baltimore, Md. : 1950), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Antigen-experienced airway CD8Science advances · 2026Article
- The ability of memory CD8 T cell subsets to numerically and functionally recover following whole body irradiation is influenced by their history of cognate antigen exposures.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Long lived liver-resident memory T cells of biased specificities for abundant sporozoite antigens drive malaria protection by radiation-attenuated sporozoite vaccination.PLoS pathogens · 2025Article
- Repetitive antigen stimulation in the periphery dictates the composition and recall responses of brain-resident memory CD8Cell reports · 2025Article
- Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms.Nature communications · 2024Article
- Induction of immortal-like and functional CAR T cells by defined factors.The Journal of experimental medicine · 2024Article
- Survival and division fate programs are preserved but retuned during the naïve to memory CD8Immunology and cell biology · 2024Article
- Senescent T cells: Beneficial and detrimental roles.Immunological reviews · 2023Review
- Article
- Inefficient Recovery of Repeatedly Stimulated Memory CD8 T Cells after Polymicrobial Sepsis Induction Leads to Changes in Memory CD8 T Cell Pool Composition.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Sepsis-induced changes in differentiation, maintenance, and function of memory CD8 T cell subsets.Frontiers in immunology · 2023Review
- Protective CD8+ T Cell Response Induced by Modified Vaccinia Virus Ankara Delivering Ebola Virus Nucleoprotein.Vaccines · 2022Article
- Optimizing the Boosting Schedule of Subunit Vaccines Consisting of BCG and "Non-BCG" Antigens to Induce Long-Term Immune Memory.Frontiers in immunology · 2022Article
- Memory CD8Immunology · 2021Article
- Monophosphoryl Lipid A and Poly I:C Combination Adjuvant Promoted Ovalbumin-Specific Cell Mediated Immunity in Mice Model.Biology · 2021Article
- Prolonged Reactive Oxygen Species Production following Septic Insult.ImmunoHorizons · 2021Observational
- Repeated Antigen Exposure Extends the Durability of Influenza-Specific Lung-Resident Memory CD8Cell reports · 2018Article
- Defining Memory CD8 T Cell.Frontiers in immunology · 2018Review
- Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.Nature communications · 2017Article
- Antigen Exposure History Defines CD8 T Cell Dynamics and Protection during Localized Pulmonary Infections.Frontiers in immunology · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
In experimental models in which the Ag-stimulation history of memory CD8 T cell populations was clearly defined (adoptive transfer of a known number of TCR-transgenic memory CD8 T cells), all facets of the ensuing CD8 T cell responses, including proliferative expansion, duration and extent of contraction, diversification of memory CD8 T cell transcriptomes, and life-long survival, were dependent on the number of prior Ag encounters. However, the extent to which sequential adoptive-transfer models reflect the physiological scenario in which memory CD8 T cells are generated by repetitive Ag challenges of individual hosts (no adoptive transfer involved) is not known. Direct comparison of endogenous memory CD8 T cell responses generated in repetitively infected hosts revealed that recurrent homologous boosting was required to preserve the numbers and increase the phenotypic and functional complexity of the developing memory CD8 T cell pool. Although life-long survival of the memory CD8 T cells was not impacted, phenotype (i.e., upregulation of CD62L) and function (i.e., homeostatic turnover, Ag-stimulated IL-2 production) of repeatedly stimulated memory CD8 T cells were dependent on time after last Ag encounter. Therefore, repetitive Ag challenges of individual hosts can substantially influence the numerical and functional attributes of polyclonal memory CD8 T cells, a notion with important implications for the design of future vaccination strategies aimed at increasing the number of protective memory CD8 T cells.
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