ArticleJournal of virology2014
Continuing reassortment leads to the genetic diversity of influenza virus H7N9 in Guangdong, China.
Article in Journal of virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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31 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A literature review of the use of environmental sampling in the surveillance of avian influenza viruses.Transboundary and emerging diseases · 2021Pooled it
- Genetic evolution and pathogenicity analysis of two natural recombinant isolates of avian influenza.Poultry science · 2026Article
- Cross-Species Transmission Potential of H4 Avian Influenza Viruses in China: Epidemiological and Evolutionary Study.Viruses · 2024Article
- Evolution of Avian Influenza Virus (H3) with Spillover into Humans, China.Emerging infectious diseases · 2023Article
- Coinfection of Chickens with H9N2 and H7N9 Avian Influenza Viruses Leads to Emergence of Reassortant H9N9 Virus with Increased Fitness for Poultry and a Zoonotic Potential.Journal of virology · 2022Article
- Reassortment Network of Influenza A Virus.Frontiers in microbiology · 2021Article
- Development of PDA Nanoparticles for H9N2 Avian Influenza BPP-V/BP-IV Epitope Peptide Vaccines: Immunogenicity and Delivery Efficiency Improvement.Frontiers in immunology · 2021Article
- Molecular Evolution, Diversity, and Adaptation of Influenza A(H7N9) Viruses in China.Emerging infectious diseases · 2018Article
- Article
- Live Poultry Trading Drives China's H7N9 Viral Evolution and Geographical Network Propagation.Frontiers in public health · 2018Article
- Molecular Markers for Interspecies Transmission of Avian Influenza Viruses in Mammalian Hosts.International journal of molecular sciences · 2017Review
- Quantitative risk analysis of the novel H7N9 virus in environments associated with H9 avian influenza virus, Zhejiang province, China.Epidemiology and infection · 2017Article
- Frequency of influenza H3N2 intra-subtype reassortment: attributes and implications of reassortant spread.BMC biology · 2016Article
- Effect of Live Poultry Market Interventions on Influenza A(H7N9) Virus, Guangdong, China.Emerging infectious diseases · 2016Article
- Sustained live poultry market surveillance contributes to early warnings for human infection with avian influenza viruses.Emerging microbes & infections · 2016Article
- Two Outbreak Sources of Influenza A (H7N9) Viruses Have Been Established in China.Journal of virology · 2016Article
- Differences in the epidemiology and virology of mild, severe and fatal human infections with avian influenza A (H7N9) virus.Archives of virology · 2016Article
- Reassortment of Avian Influenza A/H6N6 Viruses from Live Poultry Markets in Guangdong, China.Frontiers in microbiology · 2016Article
- Influenza A virus transmission via respiratory aerosols or droplets as it relates to pandemic potential.FEMS microbiology reviews · 2016Review
- Article
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledOn 30 March 2013, a novel avian influenza A H7N9 virus causing severe human respiratory infections was identified in China. Preliminary sequence analyses have shown that the virus is a reassortant of H7N9 and H9N2 avian influenza viruses. In this study, we conducted enhanced surveillance for H7N9 virus in Guangdong, China, from April to August 2013. We isolated two H7N9 viral strains from environmental samples associated with poultry markets and one from a clinical patient. Sequence analyses showed that the Guangdong H7N9 virus isolated from April to May shared high sequence similarity with other strains from eastern China. The A/Guangdong/1/2013 (H7N9) virus isolated from the Guangdong patient on 10 August 2013 was divergent from previously sequenced H7N9 viruses and more closely related to local circulating H9N2 viruses in the NS and NP genes. Phylogenetic analyses revealed that four internal genes of the A/Guangdong/1/2013 (H7N9) virus-the NS, NP, PB1, and PB2 genes-were in clusters different from those for H7N9 viruses identified previously in other provinces of China. The discovery presented here suggests that continuing reassortment led to the emergence of the A/Guangdong/1/2013 (H7N9) virus as a novel H7N9 virus in Guangdong, China, and that viral adaptation to avian and human hosts must be assessed. IMPORTANCE: In this study, we isolated and characterized the avian influenza A H7N9 virus in Guangdong, China, from April to August 2013. We show that the viruses isolated from Guangdong environmental samples and chickens from April to May 2013 were highly similar to other H7N9 strains found in eastern China. The H7N9 virus isolated from the clinical patient in Guangdong in August 2013 was divergent from previously identified H7N9 viruses, with the NS and NP genes originating from recent H9N2 viruses circulating in the province. This study provides direct evidence that continuing reassortment occurred and led to the emergence of a novel H7N9 influenza virus in Guangdong, China. These results also shed light on how the H7N9 virus evolved, which is critically important for future monitoring and tracing of viral transmission.
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