Evidence map›Paper›PMID 24829294›Full record

ArticleEuropean journal of cardiovascular nursing2015

Obesity and cognitive dysfunction in heart failure: the role of hypertension, type 2 diabetes, and physical fitness.

Michael L Alosco, Mary Beth Spitznagel, Ronald Cohen, Lawrence H Sweet, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of cardiovascular nursing, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Assessment of cognitive function in patients with heart failure: impact of clinical and sociodemographic factors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  6. Review
  7. Observational
  8. Review
  9. Article
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  11. Cerebrovascular Perfusion among Older Adults with and Without Cardiovascular Disease.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Article
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Michael L AloscoDepartment of Psychology, Kent State University, USA.
Mary Beth SpitznagelDepartment of Psychology, Kent State University, USA Department of Psychiatry, Summa Health System, Akron City Hospital, USA.
Ronald CohenDepartments of Neurology Psychiatry and the Institute on Aging, Center for Cognitive Aging and Memory, University of Florida, Gainesville, USA.
Lawrence H SweetDepartment of Psychology, University of Georgia, Athens, USA.
Richard JosephsonUniversity Hospitals Case Medical Center and Department of Medicine, Cleveland, USA Harrington Heart and Vascular Institute, Cleveland, USA Case Western Reserve University School of Medicine, Cleveland, USA.
Joel HughesDepartment of Psychology, Kent State University, USA Department of Psychiatry, Summa Health System, Akron City Hospital, USA.
Jim RosneckDepartment of Psychiatry, Summa Health System, Akron City Hospital, USA.
John GunstadDepartment of Psychology, Kent State University, USA jgunstad@kent.edu.
Kent State University · USSumma Health System · USSumma Akron City Hospital · USUniversity of Florida · USUniversity of Georgia · USUniversity School · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Cognitive Benefits of Cardiac Rehabilitation in Heart FailureR01HL089311 · NHLBI · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2008 to 2012
$2.6M
Long-Term Weight Loss Maintenance (RMI)R01DK066787 · NIDDK · MIRIAM HOSPITAL · PI WING, RENA R · 2004 to 2007
$1.6M
Cognitive Effects of Bariatric SurgeryR01DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2006 to 2009
$1.5M
Extended Effects of Bariatric Surgery on Cognitive FunctionR56DK075119 · NIDDK · KENT STATE UNIVERSITY · PI GUNSTAD, JOHN J. · 2010 to 2010
$296k
NHLBI NIH HHS R01 HL089311NIA NIH HHS P30 AG028740NIDDK NIH HHS DK075119NIDDK NIH HHS R01 DK066787NIDDK NIH HHS R01 DK075119NIDDK NIH HHS R56 DK075119PHS HHS HLO89311
6 · The paper itself

Abstract

backgroundCognitive impairment is common in heart failure. Obesity is a known risk factor for cognitive dysfunction in heart failure, though the mechanisms remain unclear. Obesity increases risk for conditions like hypertension and type 2 diabetes mellitus (T2DM) as well as poor fitness levels, and this may serve as one possible pathway accounting for association between obesity and cognitive dysfunction.

aimsWe used structural equation modeling to test whether the combination of hypertension, T2DM, and reduced fitness mediate the association between obesity and cognitive dysfunction.

methodsTwo hundred heart failure patients completed neuropsychological testing and a physical fitness assessment. Hypertension and T2DM were ascertained via self-report and medical records. Body mass index (BMI) was calculated.

resultsForty-three percent of the sample was obese. Hypertension (70%) and T2DM (36%) were common, and fitness levels were reduced. The structural equation model with these factors as mediators between BMI and cognitive function demonstrated excellent fit (comparative fit index = 0.98; root mean-square error of approximations = 0.03). Higher BMI correlated with hypertension, T2DM, and poorer fitness. Each of these factors predicted worse cognition. Models that isolated medical comorbidities and physical fitness as the mediator were weaker than the full model.

conclusionsIncreased risk for medical comorbidities and reduced fitness levels helped to explain the negative effects of obesity on cognitive dysfunction in heart failure. Prospective studies should confirm this pattern and examine how weight loss benefits cognitive function in heart failure.

Indexed as

Physical FitnessAgedAged, 80 and overBody Mass IndexCognition DisordersDiabetes Mellitus, Type 2FemaleHeart FailureHumansHypertensionMaleMiddle AgedNeuropsychological TestsObesityRisk Factorscognitive functionheart failurehypertensionobesityPhysical fitnesstype 2 diabetes mellitus

Identifiers

PMID24829294
PMCPMC4998059
OpenAlexW2042950164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.