ArticleJournal of the Royal Society, Interface2014
Within-host viral dynamics of dengue serotype 1 infection.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mathematical models for dengue fever epidemiology: A 10-year systematic review.Physics of life reviews · 2022Pooled it
- Viral Dynamic Model-Informed Dose Selection of Mosnodenvir Prophylaxis against DENV-3 in a Controlled Human Infection Model.Clinical pharmacology and therapeutics · 2026Trial
- Dengue virus: structure, genome, evolution and challenges to control and prevent transmission.Antonie van Leeuwenhoek · 2025Review
- Modelling the mechanisms of antibody mixtures in viral infections: the cases of sequential homologous and heterologous dengue infections.Journal of the Royal Society, Interface · 2024Article
- Article
- Measles Infection Dose Responses: Insights from Mathematical Modeling.Bulletin of mathematical biology · 2024Article
- Within-host models unravelling the dynamics of dengue reinfections.Infectious Disease Modelling · 2024Article
- Incorporating Intracellular Processes in Virus Dynamics Models.Microorganisms · 2024Review
- How robust are estimates of key parameters in standard viral dynamic models?PLoS computational biology · 2024Article
- Global stability of secondary DENV infection models with non-specific and strain-specific CTLs.Heliyon · 2024Article
- The effect of model structure and data availability on Usutu virus dynamics at three biological scales.Royal Society open science · 2024Article
- Markers of prolonged hospitalisation in severe dengue.PLoS neglected tropical diseases · 2024Article
- Modelling the impact of JNJ-1802, a first-in-class dengue inhibitor blocking the NS3-NS4B interaction, on in-vitro DENV-2 dynamics.PLoS computational biology · 2023Article
- Review
- Evolutionary dynamics of dengue virus in India.PLoS pathogens · 2023Article
- Heterogeneity of Rift Valley fever virus transmission potential across livestock hosts, quantified through a model-based analysis of host viral load and vector infection.PLoS computational biology · 2022Article
- Physiologically Based Pharmacokinetic/Pharmacodynamic Model for the Treatment of Dengue Infections Applied to the Broad Spectrum Antiviral Soraphen A.ACS pharmacology & translational science · 2021Article
- Article
- Article
- Antibody-dependent enhancement representing in vitro infective progeny virus titer correlates with the viremia level in dengue patients.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Dengue, the most common mosquito-borne viral infection of humans, is endemic across much of the world, including much of tropical Asia and is increasing in its geographical range. Here, we present a mathematical model of dengue virus dynamics within infected individuals, detailing the interaction between virus and a simple immune response. We fit this model to measurements of plasma viral titre from cases of primary and secondary DENV 1 infection in Vietnam. We show that variation in model parameters governing the immune response is sufficient to create the observed variation in virus dynamics between individuals. Estimating model parameter values, we find parameter differences between primary and secondary cases consistent with the theory of antibody-dependent enhancement (namely enhanced rates of viral entry to target cells in secondary cases). Finally, we use our model to examine the potential impact of an antiviral drug on the within-host dynamics of dengue. We conclude that the impact of antiviral therapy on virus dynamics is likely to be limited if therapy is only started at the onset of symptoms, owing to the typically late stage of viral pathogenesis reached by the time symptoms are manifested and thus treatment is started.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.