Evidence map›Paper›PMID 24829266›Full record

ReviewEndocrine-related cancer2014

Molecular approaches to thyroid cancer diagnosis.

Susan J Hsiao, Yuri E Nikiforov

Abstract readReview
In one paragraph

Review in Endocrine-related cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Molecular and clinicopathological characteristics ofHistology and histopathology · 2026
    Review
  3. Pathogenesis of Thyroid Cancer with Particular Emphasis on the Role of AnoikisJournal of clinical research in pediatric endocrinology · 2026
    Review
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  16. Identification of crucial genes involved in thyroid cancer development.Journal of the Egyptian National Cancer Institute · 2023
    Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Susan J HsiaoDivision of Molecular and Genomic PathologyDepartment of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA.
Yuri E NikiforovDivision of Molecular and Genomic PathologyDepartment of Pathology, University of Pittsburgh School of Medicine, 3477 Euler Way, Room 8031, Pittsburgh, Pennsylvania 15213, USA nikiforovye@upmc.edu.

Funding

Mechanisms of RET/PTC rearrangements in thyroid cancerR01CA088041 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIKIFOROV, YURI E · 2001 to 2017
$3.8M
NCI NIH HHS R01 CA088041NCI NIH HHS R01 CA88041
6 · The paper itself

Abstract

Thyroid nodules are common, and the accurate diagnosis of cancer or benign disease is important for the effective clinical management of patients. Molecular markers are a helpful diagnostic tool, particularly for cytologically indeterminate thyroid nodules. In the past few years, significant progress has been made in developing molecular markers for clinical use in fine-needle aspiration specimens, including gene mutation panels and gene expression classifiers. With the availability of next generation sequencing technology, gene mutation panels can be expanded to interrogate multiple genes simultaneously and to provide yet more accurate diagnostic information. In addition, recently several new molecular markers of thyroid cancer have been identified that offer diagnostic, prognostic, and therapeutic information that might be of value in guiding individualized management of patients with thyroid nodules.

Indexed as

Biomarkers, TumorBiopsy, Fine-NeedleGene Expression Regulation, NeoplasticHumansMutationThyroid NeoplasmsBiomarkers, Tumormolecular markerprognostic markerthyroid cancerthyroid nodule

Identifiers

PMID24829266
PMCPMC4160369

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.