ArticleJournal of biomedical materials research. Part A2015
Citrate-based biphasic scaffolds for the repair of large segmental bone defects.
Article in Journal of biomedical materials research. Part A, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Three-Dimensional Scaffolds in Treating Long Bone Defects: Evidence from Preclinical and Clinical Literature-A Systematic Review.BioMed research international · 2017Pooled it
- Targeting the osteoporotic bone microenvironment: Mechanistic insight and therapeutic biomaterials for accelerating bone regeneration.Bioactive materials · 2026Review
- Biomineralization-inspired scaffolds using citrate-based polymers to stabilize amorphous calcium phosphate promote osteogenesis and angiogenesis for bone defect repair.Bioactive materials · 2026Article
- Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Recent Progress in Advanced Polyester Elastomers for Tissue Engineering and Bioelectronics.Molecules (Basel, Switzerland) · 2023Review
- Simulation of Cortical and Cancellous Bone to Accelerate Tissue Regeneration.Advanced functional materials · 2023Article
- Article
- Engineering multifunctional bioactive citrate-based biomaterials for tissue engineering.Bioactive materials · 2023Review
- Fabrication of channeled scaffolds through polyelectrolyte complex (PEC) printed sacrificial templates for tissue formation.Bioactive materials · 2022Article
- Phototherapy and optical waveguides for the treatment of infection.Advanced drug delivery reviews · 2021Review
- Protective Role of Melatonin Against Postmenopausal Bone LossFrontiers in pharmacology · 2020Article
- Three-dimensional Printed Mg-Doped β-TCP Bone Tissue Engineering Scaffolds: Effects of Magnesium Ion Concentration on Osteogenesis and AngiogenesisTissue engineering and regenerative medicine · 2019Article
- Development of osteopromotive poly (octamethylene citrate glycerophosphate) for enhanced bone regeneration.Acta biomaterialia · 2019Article
- Citrate-based materials fuel human stem cells by metabonegenic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Citrate chemistry and biology for biomaterials design.Biomaterials · 2018Review
- Article
- Flexible biodegradable citrate-based polymeric step-index optical fiber.Biomaterials · 2017Article
- Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives.Biomaterials · 2017Article
- Fast degradable citrate-based bone scaffold promotes spinal fusion.Journal of materials chemistry. B · 2015Article
- Citrate-Based Biomaterials and Their Applications in Regenerative Engineering.Annual review of materials research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Attempts to replicate native tissue architecture have led to the design of biomimetic scaffolds focused on improving functionality. In this study, biomimetic citrate-based poly (octanediol citrate)-click-hydroxyapatite (POC-Click-HA) scaffolds were developed to simultaneously replicate the compositional and architectural properties of native bone tissue while providing immediate structural support for large segmental defects following implantation. Biphasic scaffolds were fabricated with 70% internal phase porosity and various external phase porosities (between 5 and 50%) to mimic the bimodal distribution of cancellous and cortical bone, respectively. Biphasic POC-Click-HA scaffolds displayed compressive strengths up to 37.45 ± 3.83 MPa, which could be controlled through the external phase porosity. The biphasic scaffolds were also evaluated in vivo for the repair of 10-mm long segmental radial defects in rabbits and compared to scaffolds of uniform porosity as well as autologous bone grafts after 5, 10, and 15 weeks of implantation. The results showed that all POC-Click-HA scaffolds exhibited good biocompatibility and extensive osteointegration with host bone tissue. Biphasic scaffolds significantly enhanced new bone formation with higher bone densities in the initial stages after implantation. Biomechanical and histomorphometric analysis supported a similar outcome with biphasic scaffolds providing increased compression strength, interfacial bone ingrowth, and periosteal remodeling in early time points, but were comparable to all experimental groups after 15 weeks. These results confirm the ability of biphasic scaffold architectures to restore bone tissue and physiological functions in the early stages of recovery, and the potential of citrate-based biomaterials in orthopedic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.