ArticleExperimental brain research2014
Relationship among nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained nausea.
Article in Experimental brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- Cardiac Vagal Efficiency Is Enhanced by Percutaneous Auricular Neurostimulation in Adolescents With Nausea: Moderation by Antidepressant Drug Exposure.Neurogastroenterology and motility · 2025Trial
- Use of an allostatic neurotechnology by adolescents with postural orthostatic tachycardia syndrome (POTS) is associated with improvements in heart rate variability and changes in temporal lobe electrical activity.Experimental brain research · 2016Trial
- Children and adolescents with disorders of gut-brain interaction with comorbid hypermobility and orthostatic intolerance have worse outcomes.Journal of pediatric gastroenterology and nutrition · 2026Article
- Validation of the youth version of the Alimetry® Gut-Brain Wellbeing Survey: a mental health scale for young people with chronic gastroduodenal symptoms.World journal of pediatrics : WJP · 2026Article
- Sensory signals for nausea.Trends in neurosciences · 2025Review
- Body Surface Gastric Mapping Delineates Specific Patient Phenotypes in Adolescents With Functional Dyspepsia and Gastroparesis.Neurogastroenterology and motility · 2025Article
- Endocannabinoid signaling in stress, nausea, and vomiting.Neurogastroenterology and motility · 2025Review
- Assessment of comorbid symptoms in pediatric autonomic dysfunction.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
- Sex Moderates the Relationship Between Nausea Severity and Heart Rate Variability in Adolescents and Young Adults.Digestive diseases and sciences · 2022Article
- Development and validation of the paediatric Carbohydrate Perception Questionnaire (pCPQ), an instrument for the assessment of carbohydrate-induced gastrointestinal symptoms in the paediatric population.Neurogastroenterology and motility · 2020Article
- A cross-sectional study of nausea in functional abdominal pain: relation to mucosal mast cells and psychological functioning.BMC gastroenterology · 2020Article
- Chronic nausea and orthostatic intolerance: Diagnostic utility of orthostatic challenge duration, Nausea Profile Questionnaire, and neurohumoral measures.Neurogastroenterology and motility · 2018Article
- Development and Validation of a Nausea Severity Scale for Assessment of Nausea in Children with Abdominal Pain-Related Functional Gastrointestinal Disorders.Children (Basel, Switzerland) · 2018Article
- 'Visual clutter' in the classroom: voices of students with Autism Spectrum Disorder.International journal of developmental disabilities · 2018Article
- Nausea in Children With Functional Abdominal Pain Predicts Poor Health Outcomes in Young Adulthood.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2017Article
- What is nausea? A historical analysis of changing views.Autonomic neuroscience : basic & clinical · 2017Review
- Functional Nausea in Children: A Review of the Literature and Need for Diagnostic Criteria.Children (Basel, Switzerland) · 2016Review
- Distinct neurohumoral biomarker profiles in children with hemodynamically defined orthostatic intolerance may predict treatment options.American journal of physiology. Heart and circulatory physiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This study evaluated the relationship among nausea, anxiety, and orthostatic symptoms in pediatric patients with chronic unexplained nausea. We enrolled 48 patients (36 females) aged 15 ± 2 years. Patients completed the Nausea Profile, State-Trait Anxiety Inventory for Children and underwent 70° head upright tilt testing (HUT) to assess for orthostatic intolerance (OI) and measure heart rate variability (HRV). We found nausea to be significantly associated with trait anxiety, including total nausea score (r = 0.71, p < 0.01) and 3 subscales: somatic (r = 0.64, p < 0.01), gastrointestinal (r = 0.48, p = 0.01), and emotional (r = 0.74, p < 0.01). Nausea was positively associated with state anxiety, total nausea (r = 0.55, p < 0.01), somatic (r = 0.48, p < .01), gastrointestinal (r = .30, p < .05), and emotional (r = .64, p < .01) subscales. Within 10 min of HUT, 27 patients tested normal and 21 demonstrated OI. After 45 min of HUT, only 13 patients (27%) remained normal. Nausea reported on the Nausea Profile before HUT was associated with OI measured at 10 min of tilt (nausea total r = 0.35, p < 0.05; nausea emotional subscale r = 0.40, p < 0.01) and lower HRV at 10 min of HUT (F = 6.39, p = 0.01). We conclude that nausea is associated with both anxiety symptoms and OI. The finding of decreased HRV suggests an underlying problem in autonomic nervous system function in children and adolescents with chronic unexplained nausea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.