Trial reportJournal of anesthesia2014
Intravenous dezocine pretreatment reduces the incidence and intensity of myoclonus induced by etomidate.
Trial report in Journal of anesthesia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Comparison of the Effectiveness of Various Drug Interventions to Prevent Etomidate-Induced Myoclonus: A Bayesian Network Meta-Analysis.Frontiers in medicine · 2022Pooled it
- Using dezocine to prevent etomidate-induced myoclonus: a meta-analysis of randomized trials.Drug design, development and therapy · 2017Pooled it
- Effect of dexmedetomidine on etomidate-induced myoclonus: a randomized, double-blind controlled trial.Drug design, development and therapy · 2019Trial
- Oxycodone for prevention of etomidate-induced myoclonus: a randomized double-blind controlled trial.The Journal of international medical research · 2018Trial
- Dezocine as a potent analgesic: overview of its pharmacological characterization.Acta pharmacologica Sinica · 2022Review
- Etomidate and its Analogs: A Review of Pharmacokinetics and Pharmacodynamics.Clinical pharmacokinetics · 2021Review
- Effects of dezocine on PAED scale and Ramsay sedation scores in patients undergoing NUSS procedure.American journal of translational research · 2021Article
- Pretreatment with Nalbuphine Prevents Sufentanil-Induced Cough During the Anesthesia Induction: A Randomized Controlled Trial.Therapeutics and clinical risk management · 2020Article
- Comparison of the Effects of Low-Dose Midazolam, Magnesium Sulfate, Remifentanil and Low-Dose Etomidate on Prevention of Etomidate-Induced Myoclonus in Orthopedic Surgeries.Anesthesiology and pain medicine · 2016Article
- Effect of Fentanyl and Nalbuphine for Prevention of Etomidate-Induced Myoclonus.Anesthesia, essays and researchesArticle
- Nalbuphine pretreatment for prevention of etomidate induced myoclonus: A prospective, randomized and double-blind study.Journal of anaesthesiology, clinical pharmacologyArticle
- Effect of etomidate and propofol on airway mechanics during induction - A prospective randomized trial.Journal of anaesthesiology, clinical pharmacologyArticle
Corrections and comments
- Erratum issuedLu, Zhifeng [Corrected to Lv, Zhifeng]
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the suppressive effect of intravenous dezocine on the incidence and severity of myoclonic movements induced by etomidate, a total of 80 patients, American Society of Anesthesiologists physical status I-II, were randomized into two equally sized groups (n = 40). These two groups were assigned to give either intravenous dezocine 0.1 mg/kg or a matching placebo (equal volume of 0.9% saline) 30 s before administration of etomidate. For anesthesia induction, 0.3 mg/kg etomidate was injected over a period of 1 min. One minute after etomidate administration, the severity of myoclonus was assessed. Pretreatment with dezocine significantly reduced both the incidence and intensity of myoclonus. These results demonstrate that intravenous dezocine 0.1 mg/kg 30 s prior to induction was effective in suppressing myoclonic movements in our patients.
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Registered trials
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