ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2014
The value of transcranial Doppler imaging in children with tuberculous meningitis.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- A systemic review of tuberculosis with HIV coinfection in children.Pediatric radiology · 2017Pooled it
- Clinical Applications of Point-of-Care and Diagnostic Transcranial Doppler in the Pediatric Acute Care Setting: A Scoping Review.Neurocritical care · 2026Article
- Risk factors of poor developmental outcome in children with tuberculous meningitis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Clinical applications of transcranial Doppler in non-trauma critically ill children: a scoping review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021Article
- Transcranial Doppler Use in Non-traumatic Critically Ill Children: A Multicentre Descriptive Study.Frontiers in pediatrics · 2021Article
- Transcranial Doppler for Monitoring and Evaluation of Idiopathic Intracranial Hypertension.Journal of neurosciences in rural practice · 2020Article
- Knowledge gaps and research priorities in tuberculous meningitis.Wellcome open research · 2019Article
- Standardized Methods for Enhanced Quality and Comparability of Tuberculous Meningitis Studies.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2017Review
- Role of Transcranial Doppler in the Evaluation of Vasculopathy in Tuberculous Meningitis.PloS one · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTranscranial Doppler imaging (TCDI) is potentially a valuable investigational tool in children with tuberculous meningitis (TBM), a condition often complicated by pathology relevant to Doppler imaging such as raised intracranial pressure (ICP) and cerebral vasculopathies.
methodsSerial TCDI was performed on 20 TBM children with the aim of investigating cerebrovascular haemodynamics and the relationship between pulsatility index (PI) and ICP.
resultsWe observed a poor correlation between ICP and PI in children with communicating hydrocephalus (p = 0.72). No decline in PI was noted following 7 days of medical therapy for communicating hydrocephalus (p = 0.78) despite a concomitant decline in ICP. Conversely, a decline in PI was noted in all four children with non-communicating hydrocephalus who underwent cerebrospinal fluid diversion. High blood flow velocities (BFV) in all the basal cerebral arteries were observed in 14 children (70 %). The high BFV persisted for 7 days suggesting stenosis due to vasculitis rather than functional vasospasm. Complete middle cerebral artery (MCA) occlusion, subnormal mean MCA velocities (<40 cm/s) and PIs (<0.4) correlated with radiologically proven large cerebral infarcts.
conclusionsTCDI-derived PI is not a reliable indicator of raised ICP in children with tuberculous hydrocephalus. This may be attributed to individual variation of tuberculous vascular disease, possibly compromising cerebral vascular compliance and resistance. Basal artery stenosis secondary to vasculitis is observed during the acute stage of TBM in the majority of children.
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