ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Excitatory synaptic feedback from the motor layer to the sensory layers of the superior colliculus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Multiple groups of neurons in the superior colliculus convert value signals into saccadic vigor.iScience · 2026Article
- Diverse and dynamic influences of saccades on visual representations in the mouse superior colliculus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pathways from the Superior Colliculus to the Basal Ganglia.Current neuropharmacology · 2024Review
- Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo.eLife · 2023Article
- What Are the Functions of the Superior Colliculus and Its Involvement in Neurologic Disorders?Neurology · 2023Article
- The Superior Colliculus: Cell Types, Connectivity, and Behavior.Neuroscience bulletin · 2022Review
- The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action.Current biology : CB · 2021Review
- Unraveling circuits of visual perception and cognition through the superior colliculus.Neuron · 2021Review
- Monosynaptic inputs to specific cell types of the intermediate and deep layers of the superior colliculus.The Journal of comparative neurology · 2020Article
- Sensorimotor transformation elicits systematic patterns of activity along the dorsoventral extent of the superior colliculus in the macaque monkey.Communications biology · 2019Article
- Distinct cell types in the superficial superior colliculus project to the dorsal lateral geniculate and lateral posterior thalamic nuclei.Journal of neurophysiology · 2018Article
- Gentle Handling Attenuates Innate Defensive Responses to Visual Threats.Frontiers in behavioral neuroscience · 2018Article
- Integrating Brain and Biomechanical Models-A New Paradigm for Understanding Neuro-muscular Control.Frontiers in neuroscience · 2018Article
- Circuits for Action and Cognition: A View from the Superior Colliculus.Annual review of vision science · 2017Review
- A circuit for saccadic suppression in the primate brain.Journal of neurophysiology · 2017Article
- A neural locus for spatial-frequency specific saccadic suppression in visual-motor neurons of the primate superior colliculus.Journal of neurophysiology · 2017Article
- How is visual salience computed in the brain? Insights from behaviour, neurobiology and modelling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- A sodium afterdepolarization in rat superior colliculus neurons and its contribution to population activity.Journal of neurophysiology · 2016Article
- A Microsaccadic Account of Attentional Capture and Inhibition of Return in Posner Cueing.Frontiers in systems neuroscience · 2016Article
- An integrative role for the superior colliculus in selecting targets for movements.Journal of neurophysiology · 2015Review
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Authors and funding
6 authors.
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Abstract
Neural circuits that translate sensory information into motor commands are organized in a feedforward manner converting sensory information into motor output. The superior colliculus (SC) follows this pattern as it plays a role in converting visual information from the retina and visual cortex into motor commands for rapid eye movements (saccades). Feedback from movement to sensory regions is hypothesized to play critical roles in attention, visual image stability, and saccadic suppression, but in contrast to feedforward pathways, motor feedback to sensory regions has received much less attention. The present study used voltage imaging and patch-clamp recording in slices of rat SC to test the hypothesis of an excitatory synaptic pathway from the motor layers of the SC back to the sensory superficial layers. Voltage imaging revealed an extensive depolarization of the superficial layers evoked by electrical stimulation of the motor layers. A pharmacologically isolated excitatory synaptic potential in the superficial layers depended on stimulus strength in the motor layers in a manner consistent with orthodromic excitation. Patch-clamp recording from neurons in the sensory layers revealed excitatory synaptic potentials in response to glutamate application in the motor layers. The location, size, and morphology of responsive neurons indicated they were likely to be narrow-field vertical cells. This excitatory projection from motor to sensory layers adds an important element to the circuitry of the SC and reveals a novel feedback pathway that could play a role in enhancing sensory responses to attended targets as well as visual image stabilization.
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