ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Expression and functional roles of Kv7/KCNQ/M-channels in rat medial entorhinal cortex layer II stellate cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 25 citations in OpenAlex.
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- Effects of moderate static magnetic fields on voltage-gated potassium ion channels in sympathetic neuron-like PC12 cells.Physiological reports · 2025Article
- Glycine-induced activation of GPR158 increases the intrinsic excitability of medium spiny neurons in the nucleus accumbens.Cellular and molecular life sciences : CMLS · 2024Article
- Entorhinal cortical delta oscillations drive memory consolidation.Cell reports · 2023Article
- Modulation of motor behavior by the mesencephalic locomotor region.Cell reports · 2021Article
- Beneficial effect of retigabine on memory in rats receiving ethanol.Pharmacological reports : PR · 2021Article
- Topographical Organization of M-Current on Dorsal and Median Raphe Serotonergic Neurons.Frontiers in cellular neuroscience · 2021Article
- Characterization of functional subgroups among genetically identified cholinergic neurons in the pedunculopontine nucleus.Cellular and molecular life sciences : CMLS · 2019Article
- Modulation of Kv7 channels and excitability in the brain.Cellular and molecular life sciences : CMLS · 2017Review
- Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E.The Journal of physiology · 2017Article
- Electrical resonance with voltage-gated ion channels: perspectives from biophysical mechanisms and neural electrophysiology.Acta pharmacologica Sinica · 2016Review
- Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The M-current contributes to high threshold membrane potential oscillations in a cell type-specific way in the pedunculopontine nucleus of mice.Frontiers in cellular neuroscience · 2015Article
- Decoding brain state transitions in the pedunculopontine nucleus: cooperative phasic and tonic mechanisms.Frontiers in neural circuits · 2015Article
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3 authors at 1 institution in 1 country.
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Abstract
The medial entorhinal cortex (MEC) is important for spatial navigation and memory. Stellate cells (SCs) of MEC layer II provide major input to the hippocampus, and are thought to be the neuronal correlate of the grid cells. Their electrophysiological properties have been used to explain grid field formation. However, little is known about the functional roles of potassium channels in SCs. M-current is a slowly activating potassium current, active at subthreshold potentials. Although some studies have suggested that Kv7/M-channels may affect subthreshold resonance in SCs, others have found no Kv7/M-current in these cells, so the expression and roles of Kv7/M-channels in SCs are still debated. Using whole-cell voltage-clamp, we have identified a typical M-current with pharmacological properties characteristic of Kv7/M-channels in rat MEC SCs. Current-clamp experiments showed that the specific Kv7/M-channel blocker XE991 increased SCs excitability, and reduced spike frequency adaptation. Our results demonstrate that Kv7/M-channels are expressed in SCs and contribute substantially to regulation of excitability in these cells.
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