ArticleNature communications2014
Epistasis and natural selection shape the mutational architecture of complex traits.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 148 citations in OpenAlex.
- Multi-parent mapping reveals epistatic architecture and elite haplotypes for multi-trait improvement in cotton.Genome biology · 2026Article
- Persistent selection on size explains micro- and macroevolutionary alignments in fly wings.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Free energy perturbations in enzyme kinetic models reveal cryptic epistasis.PLoS computational biology · 2026Article
- Selection for Molecularly Complementary Modules (MCMs) Drives the Origins and Evolution of Pleiofunctional, Epistatic Interactomes (PEIs).Life (Basel, Switzerland) · 2026Review
- Developmental lines of least resistance predict standing genetic covariation but do not constrain plasticity or rapid evolution.Proceedings. Biological sciences · 2025Article
- Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Longitudinal sequencing reveals polygenic and epistatic nature of genomic response to selection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Alternative Mutational Architectures Producing Identical M-Matrices can Lead to Different Patterns of Evolutionary Divergence.Genome biology and evolution · 2025Article
- Macroevolution along developmental lines of least resistance in fly wings.Nature ecology & evolution · 2025Article
- Quantifying Genetic Parameters for Blackleg Resistance in Rapeseed: A Comparative Study.Plants (Basel, Switzerland) · 2024Article
- Divergence in evolutionary potential of life history traits among wild populations is predicted by differences in climatic conditions.Evolution letters · 2024Article
- Developmental bias as a cause and consequence of adaptive radiation and divergence.Frontiers in cell and developmental biology · 2024Review
- The evolution of genetic covariance and modularity as a result of multigenerational environmental fluctuation.Evolution letters · 2023Article
- Article
- Detecting natural selection in trait-trait coevolution.BMC ecology and evolution · 2023Article
- Article
- Developmental bias predicts 60 million years of wing shape evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Variation in mutational (co)variances.G3 (Bethesda, Md.) · 2023Article
- Evolvability and trait function predict phenotypic divergence of plant populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolvability and constraint in the evolution of three-dimensional flower morphology.American journal of botany · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The evolutionary trajectories of complex traits are constrained by levels of genetic variation as well as genetic correlations among traits. As the ultimate source of all genetic variation is mutation, the distribution of mutations entering populations profoundly affects standing variation and genetic correlations. Here we use an individual-based simulation model to investigate how natural selection and gene interactions (that is, epistasis) shape the evolution of mutational processes affecting complex traits. We find that the presence of epistasis allows natural selection to mould the distribution of mutations, such that mutational effects align with the selection surface. Consequently, novel mutations tend to be more compatible with the current forces of selection acting on the population. These results suggest that in many cases mutational effects should be seen as an outcome of natural selection rather than as an unbiased source of genetic variation that is independent of other evolutionary processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.