ArticleJournal of clinical gastroenterology
Adherence during antiviral treatment regimens for chronic hepatitis C: a qualitative study of patient-reported facilitators and barriers.
Article in Journal of clinical gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Convenience, rapport and skill: effective rural hepatitis C treatment, qualitative findings from a mobile harm reduction-informed tele-medicine intervention in Northern New England, 2022-2024.Harm reduction journal · 2026Trial
- A cross-sectional survey on exploring adherence to diabetes treatment regimens: Insights from Hail region, Saudi Arabia.Medicine · 2026Article
- Barriers and Facilitators to Hepatitis C Virus Treatment in Los Angeles County.Research square · 2026Article
- Predictors of Medication Non-Adherence Among Hepatitis B Patients in South Sudan: A Health-Facility-Based Cross-Sectional Study.Patient preference and adherence · 2025Article
- Factors Associated with Hepatitis B Medication Adherence and Persistence among Underserved Chinese and Vietnamese Americans.Journal of clinical medicine · 2022Article
- A Scoping Review Investigating Relationships between Depression, Anxiety, and the PrEP Care Continuum in the United States.International journal of environmental research and public health · 2021Article
- Factors Contributing to Medication Adherence in Patients with a Chronic Condition: A Scoping Review of Qualitative Research.Pharmaceutics · 2021Article
- A Systematic Review of Patient-Reported Outcomes in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.Hepatology communications · 2020Article
- Network-based recruitment of people who inject drugs for hepatitis C testing and linkage to care.Journal of viral hepatitis · 2020Article
- Engagement in the Hepatitis C care continuum among people who use drugs.Journal of substance use · 2020Article
- Content Validity and Reliability of a Self-Report Measure of Medication Nonadherence in Hepatitis C Treatment.Digestive diseases and sciences · 2019Article
- Determinants of Hepatitis C Treatment Adherence and Treatment Completion Among Veterans in the Direct Acting Antiviral Era.Digestive diseases and sciences · 2019Article
- Article
- HCV compliance and treatment success rates are higher with DAAs in structured HCV clinics compared to general hepatology clinics.Medicine · 2019Article
- A Bitter Pill to Swallow: Why Medication Safety Is Critical in Hepatitis C Treatment.P & T : a peer-reviewed journal for formulary management · 2018Article
- Development and Pilot-Testing of a Cognitive Behavioral Coping Skills Group Intervention for Patients with Chronic Hepatitis C.Contemporary clinical trials communications · 2017Article
- Value of Sustained Virologic Response in Patients with Hepatitis C as a Function of Time to Progression of End-Stage Liver Disease.Clinical drug investigation · 2017Article
- The Australasian Hepatology Association consensus guidelines for the provision of adherence support to patients with hepatitis C on direct acting antivirals.Patient preference and adherence · 2016Article
- "Fighting an uphill battle": experience with the HCV triple therapy: a qualitative thematic analysis.BMC infectious diseases · 2014Article
- Providing Hepatitis C Treatment Locally for Substance-Using Patients.Journal of primary care & community healthArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
goalsTo understand patients' perceptions of factors which facilitate and hinder adherence to inform adherence-enhancing interventions.
backgroundAdherence to antiviral therapy for hepatitis C viral infection is critical to achieving a sustained virological response. However, persistence with and adherence to antiviral regimens can pose challenges for patients that interfere with sustained virological response. STUDY: A qualitative analysis of 21 semistructured patient interviews using open-ended questions and specific follow-up probes was conducted. Interviews were audio-recorded, transcribed, and content-analyzed iteratively to determine frequent and salient themes.
resultsThree broad themes emerged: (1) missing doses and dose-timing errors; (2) facilitators of adherence; and (3) barriers to adherence. Open-ended questioning revealed few dose-timing deviations, but more specific probes uncovered several more occurrences of delays in dosing. Facilitators of adherence fell into 2 broad categories: (a) patient knowledge and motivation; and (b) practical behavioral strategies and routines. Facilitators were noted post hoc to be consistent with the Information-Motivation-Behavioral Skills Model of Adherence. Barriers to adherence involved changes in daily routine, being preoccupied with family or work responsibilities, and sleeping through dosing times. A few patients reported skipping doses due to side effects. Patients with previous hepatitis C virus treatment experience may have fewer dose-timing errors. Finally, a high level of anxiety among some patients was discovered regarding dosing errors. Emotional and informational support from clinical and research staff was key to assuaging patient fears.
conclusionThis qualitative study improves our understanding of patients' perspectives regarding adhering to hepatitis C treatment and can lead to the development of adherence-enhancing interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.