ReviewProteomics. Clinical applications2014
Uncovering the molecular networks in periodontitis.
Review in Proteomics. Clinical applications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Risk of cancer in periodontal disease: an umbrella review of meta-analyses.Frontiers in immunology · 2026Pooled it
- Epigenetic regulation of inflammation in localized aggressive periodontitis.Clinical epigenetics · 2017Trial
- Traditional medicine and natural product based therapeutics in gingivitis management and microbial interactions.Frontiers in antibiotics · 2026Review
- Interplay between survival and regulated cell death mechanisms during periodontitis progression: a systematic review.The Japanese dental science review · 2025Review
- Exploring the Causal Relationship Between Blood Metabolites and Chronic Periodontitis: Insights From Genetic Causal Analysis.Journal of cellular and molecular medicine · 2025Article
- Pro-Inflammatory and Anti-Inflammatory Interleukins in Periodontitis: Molecular Roles, Immune Crosstalk, and Therapeutic Perspectives.International journal of molecular sciences · 2025Review
- Evaluation of salivary Ki-67 in health and periodontitis.BMC oral health · 2025Article
- The Influence of Orthodontic Treatment on Periodontal Health between Challenge and Synergy: A Narrative Review.Dentistry journal · 2024Review
- Mesenchymal stem cell-derived apoptotic bodies alleviate alveolar bone destruction by regulating osteoclast differentiation and function.International journal of oral science · 2023Article
- Multispecies biofilm behavior and host interaction support the association of Tannerella serpentiformis with periodontal health.Molecular oral microbiology · 2023Article
- Association between Caspase-1, TNF-α Salivary Level and Their Diagnostic Potential to Discriminate Periodontitis from Healthy Control.Oral health & preventive dentistry · 2023Article
- Role of prebiotic dietary fiber in periodontal disease: A systematic review of animal studies.Frontiers in nutrition · 2023Review
- Stimulation of Human Periodontal Ligament Fibroblasts Using Purified Dentilisin Extracted fromBio-protocol · 2022Article
- [Salivary Metabolic Profiling in Patients with Periodontitis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Article
- Classifying Integrated Signature Molecules in Macrophages of Rheumatoid Arthritis, Osteoarthritis, and Periodontal Disease: An Omics-Based Study.Current issues in molecular biology · 2022Article
- Oral microbiota populations of adult dogs consuming wet or dry foods.Journal of animal science · 2022Article
- Comparison of oral metabolome profiles of stimulated saliva, unstimulated saliva, and mouth-rinsed water.Scientific reports · 2022Article
- 20 abnormal metabolites of Stage IV Grade C periodontitis was discovered by CPSI-MS.Pathology oncology research : POR · 2022Article
- Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Pyrroloquinoline quinone inhibits ligature-induced alveolar bone loss through regulation of redox balance and cell senescence.American journal of translational research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Periodontitis is a complex immune-inflammatory disease that results from a preestablished infection in gingiva, mainly due to Gram-negative bacteria that colonize deeper in gingival sulcus and latter periodontal pocket. Host inflammatory and immune responses have both protective and destructive roles. Although cytokines, prostaglandins, and proteases struggle against microbial burden, these molecules promote connective tissue loss and alveolar bone resorption, leading to several histopathological changes, namely destruction of periodontal ligament, deepening of periodontal pocket, and bone loss, which can converge to attain tooth loss. Despite the efforts of genomics, transcriptomics, proteomics/peptidomics, and metabolomics, there is no available biomarker for periodontitis diagnosis, prognosis, and treatment evaluation, which could assist on the established clinical evaluation. Nevertheless, some genes, transcripts, proteins and metabolites have already shown a different expression in healthy subjects and in patients. Though, so far, 'omics approaches only disclosed the host inflammatory response as a consequence of microbial invasion in periodontitis and the diagnosis in periodontitis still relies on clinical parameters, thus a molecular tool for assessing periodontitis lacks in current dental medicine paradigm. Saliva and gingival crevicular fluid have been attracting researchers due to their diagnostic potential, ease, and noninvasive nature of collection. Each one of these fluids has some advantages and disadvantages that are discussed in this review.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.