Evidence map›Paper›PMID 24828063›Full record

SynthesisPloS one2014

Alteration of fractional anisotropy and mean diffusivity in glaucoma: novel results of a meta-analysis of diffusion tensor imaging studies.

Ke Li, Cuixin Lu, Yufei Huang, Li Yuan, Dong Zeng, Kan Wu

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07748819 (MRI Evaluation of Optic Neuritis), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07748819 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

MRI Evaluation of Optic Neuritis : Integrating Double Inversion Recovery and Diffusion Tensor Imaging .

TypeobservationalSponsorAssiut UniversityRan2026 to 2028Enrolled56ConditionsOptic Nerve DiseaseArmsMRI
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  6. Tractometry of Human Visual White Matter Pathways in Health and Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
  7. Review
  8. Diffusion tensor imaging of optic neuropathies: a narrative review.Quantitative imaging in medicine and surgery · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ke LiKey Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu, China; School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Cuixin LuSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Yufei HuangSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Li YuanSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Dong ZengKey Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu, China; School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Kan WuSchool of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
University of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe hypothesized that a meta-analysis of existing studies may help to reveal significant changes on diffusion tensor imaging (DTI) in patients with glaucoma. Therefore, a meta-analysis was utilized to investigate the possibility that DTI can detect white matter damage in patients with glaucoma.

methodsThe study design and report adhered to the PRISMA Statement guidelines. DTI studies that compared glaucoma patients and controls were surveyed using PubMed, Web of Science and EMBASE (January 2008 to September 2013). Stata was used to analyze the decrease in fractional anisotropy (FA) and increase in mean diffusivity (MD) in the optic nerve and optic radiation in patients with glaucoma.

resultsEleven DTI studies were identified through a comprehensive literature search, and 10 independent DTI studies of glaucoma patients were eligible for the meta-analysis. A random effects model revealed a significant FA reduction in the optic nerve and optic radiation, as well as a significant MD increase in the tracts. A heterogeneity analysis suggested that FA may be related to glaucoma severity.

conclusionsOur findings revealed that the optic nerve and optic radiation were vulnerable regions in patients with glaucoma and that FA may be correlated with glaucoma severity and age. Furthermore, this study suggests that magnetic resonance imaging in patients with glaucoma may help to provide objective evidence to aid in the diagnosis and management of glaucoma.

Indexed as

AdultAnisotropyDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingFemaleGlaucomaHumansMaleMiddle AgedNerve FibersOptic NerveOptic Nerve Diseases

Identifiers

PMID24828063
PMCPMC4020845
OpenAlexW2046625627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.