ArticleJournal of child psychology and psychiatry, and allied disciplines2015
Prenatal depression and 5-HTTLPR interact to predict dysregulation from 3 to 36 months--a differential susceptibility model.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03434457 (Maternal Adversity, Vulnerability and Neurodevelopment), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Maternal Adversity, Vulnerability and Neurodevelopment
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Early Predictors of the Childhood Dysregulation Profile: A Systematic Review.Clinical child and family psychology review · 2026Pooled it
- Moderators and mediators of the relationship between parental depression and children's emotion dysregulation: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Maternal perinatal depression and infant self-regulation: A meta-analytic review.Development and psychopathology · 2025Review
- Prenatal mental health and emotional experiences during the pandemic: associations with infant neurodevelopment screening results.Pediatric research · 2024Article
- Exploring the impact of antenatal micronutrients used as a treatment for maternal depression on infant temperament in the first year of life.Frontiers in nutrition · 2024Article
- Long-Term Effects of Maternal Depression during Postpartum and Early Parenthood Period on Child Socioemotional Development.Children (Basel, Switzerland) · 2023Article
- Epidemiology, Etiology and Intervention Strategies for Peri-Partum Depression in Mothers.Journal of clinical medicine · 2023Article
- Prenatal programming of environmental sensitivity.Translational psychiatry · 2023Review
- The interaction between the major vault protein rs4788186 polymorphism, alcohol dependence, and depression among male Chinese problem drinkers.Frontiers in psychiatry · 2023Article
- Impact of the Timing of Maternal Peripartum Depression on Infant Social and Emotional Development at 18 Months.Journal of clinical medicine · 2022Article
- The Pandemial babies: effects of maternal stress on temperament of babies gestated and born during the pandemic.Current psychology (New Brunswick, N.J.) · 2022Article
- The Interaction BetweenFrontiers in psychiatry · 2022Article
- Development of Infant High-Intensity Fear and Fear Regulation from 6 to 24 Months: Maternal Sensitivity and Depressive Symptoms as Moderators.Research on child and adolescent psychopathology · 2021Article
- Dopamine D4 receptor gene polymorphism (DRD4 VNTR) moderates real-world behavioural response to the food retail environment in children.BMC public health · 2021Article
- Interaction Between Prematurity and the MAOA Gene on Mental Development in Children: A Longitudinal View.Frontiers in pediatrics · 2020Article
- Genetic Risk Factors for Poor Cognitive Development in Children With Low Birth Weight.Biological research for nursing · 2020Article
- Translating basic research knowledge on the biological embedding of early-life stress into novel approaches for the developmental programming of lifelong health.Psychoneuroendocrinology · 2019Review
- Associations of Prenatal and Postnatal Maternal Depressive Symptoms with Offspring Cognition and Behavior in Mid-Childhood: A Prospective Cohort Study.International journal of environmental research and public health · 2019Article
- Prenatal stress and enhanced developmental plasticity.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Shared genetic factors, fetal programming, and the transmission of depression.The lancet. Psychiatry · 2018Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundChildhood dysregulation, which reflects deficits in the capacity to regulate or control one's thoughts, emotions and behaviours, is associated with psychopathology throughout childhood and into adulthood. Exposures to adversity during the prenatal period, including prenatal depression, can influence the development of dysregulation, and a number of candidate genes have been suggested as moderators of prenatal exposure, including polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). We examined whether prenatal depression and child 5-HTTLPR interact to predict childhood dysregulation.
methodSample of N = 213 mother-child pairs from the Maternal Adversity, Vulnerability and Neurodevelopment (MAVAN) project. Mothers reported the IBQ-R at 3 and 6 months, and the ECBQ at 18 and 36 months, from which measures of dysregulation were extracted. Mothers' self-reported symptoms of depression on the CES-D at 24-36 weeks of gestation, and at 6, 12, 24 and 36 months postnatal. 5-HTTLPR genotype was extracted from buccal swabs. Mixed-model and confirmatory analyses were conducted.
resultsPrenatal depression and 5-HTTLPR interacted to predict dysregulation from 3 to 36 months, within a model of strong differential susceptibility.
conclusionChildren with S or LG alleles, when exposed to prenatal depression, have higher levels of dysregulation, and when exposed to lower or little prenatal depression, have higher capacity for regulation. Our findings support efforts to identify, support and treat prenatal depression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.