ArticleThe European journal of neuroscience2014
Cholinergic excitation in mouse primary vs. associative cortex: region-specific magnitude and receptor balance.
Article in The European journal of neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Cholinergic signaling differentially regulates a vocal motor pallial nucleus to stabilize adult birdsong.Communications biology · 2026Article
- Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine.Addiction biology · 2025Article
- Linking altered neuronal and synaptic properties to nicotinic receptor Alpha5 subunit gene dysfunction: a translational investigation in rat mPFC and human cortical layer 6.Translational psychiatry · 2025Article
- Xanomeline restores endogenous nicotinic acetylcholine receptor signaling in mouse prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
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- Layer 6A Pyramidal Cell Subtypes Form Synaptic Microcircuits with Distinct Functional and Structural Properties.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Cell-Type Specific Neuromodulation of Excitatory and Inhibitory NeuronsFrontiers in neural circuits · 2022Article
- Input dependent modulation of olfactory bulb activity by HDB GABAergic projections.Scientific reports · 2020Article
- Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits Is Cooperative and Cell-Specific.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Similar nicotinic excitability responses across the developing hippocampal formation are regulated by small-conductance calcium-activated potassium channels.Journal of neurophysiology · 2018Article
- Cholinergic Modulation of Cortical Microcircuits Is Layer-Specific: Evidence from Rodent, Monkey and Human Brain.Frontiers in neural circuits · 2017Review
- Monoaminergic Modulation of Motor Cortex Function.Frontiers in neural circuits · 2017Review
- Molecular and Cellular Mechanisms of Rapid-Acting Antidepressants Ketamine and Scopolamine.Current neuropharmacology · 2017Review
- Layer-specific cholinergic control of human and mouse cortical synaptic plasticity.Nature communications · 2016Article
- Carbachol-Induced Reduction in the Activity of Adult Male Zebra Finch RA Projection Neurons.Neural plasticity · 2016Article
- Impaired Cholinergic Excitation of Prefrontal Attention Circuitry in the TgCRND8 Model of Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors.Frontiers in cellular neuroscience · 2015Article
- The role of nicotinic acetylcholine receptors in autosomal dominant nocturnal frontal lobe epilepsy.Frontiers in physiology · 2015Review
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Authors and funding
3 authors at 3 institutions in 1 country.
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Abstract
Cholinergic stimulation of the cerebral cortex is essential for tasks requiring attention; however, there is still some debate over which cortical regions are required for such tasks. There is extensive cholinergic innervation of both primary and associative cortices, and transient release of acetylcholine (ACh) is detected in deep layers of the relevant primary and/or associative cortex, depending on the nature of the attention task. Here, we investigated the electrophysiological effects of ACh in layer VI, the deepest layer, of the primary somatosensory cortex, the primary motor cortex, and the associative medial prefrontal cortex. Layer VI pyramidal neurons are a major source of top-down modulation of attention, and we found that the strength and homogeneity of their direct cholinergic excitation was region-specific. On average, neurons in the primary cortical regions showed weaker responses to ACh, mediated by a balance of contributions from both nicotinic and muscarinic ACh receptors. Conversely, neurons in the associative medial prefrontal cortex showed significantly stronger excitation by ACh, mediated predominantly by nicotinic receptors. The greatest diversity of responses to ACh was found in the primary somatosensory cortex, with only a subset of neurons showing nicotinic excitation. In a mouse model with attention deficits only under demanding conditions, cholinergic excitation was preserved in primary cortical regions but not in the associative medial prefrontal cortex. These findings demonstrate that the effect of ACh is not uniform throughout the cortex, and suggest that its ability to enhance attention performance may involve different cellular mechanisms across cortical regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.