ArticlePloS one2014
Effects of chronic fluoxetine treatment on neurogenesis and tryptophan hydroxylase expression in adolescent and adult rats.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents - systematic review and meta-analysis.Pharmacological reports : PR · 2022Pooled it
- Reinforcement sensitivity phenotype modulates the impact of chronic stress on hedonic capacity in rats, but not the response to fluoxetine.Psychopharmacology · 2026Article
- Regional brain morphology and current antidepressant use: findings from 32 international cohorts from the ENIGMA major depressive disorder working group.Molecular psychiatry · 2025Article
- An approach to screen susceptible rats and efficacy of an antidepressive treatment after chronic stress.IBRO neuroscience reports · 2025Article
- Juvenile fluoxetine treatment affects the maturation of the medial prefrontal cortex and behavior of adolescent female rats.Pharmacological reports : PR · 2025Article
- Article
- Nicotine and fluoxetine alter adolescent dopamine-mediated behaviors via 5-HTFrontiers in psychiatry · 2024Article
- The Effect of a Diet Enriched withCurrent issues in molecular biology · 2023Article
- Disturbance of neurotransmitter metabolism in drug-naïve, first-episode major depressive disorder: a comparative study on adult and adolescent cohorts.European archives of psychiatry and clinical neuroscience · 2022Article
- Long-Term Fluoxetine Administration Causes Substantial Lipidome Alteration of the Juvenile Macaque Brain.International journal of molecular sciences · 2021Article
- Serotonin Transporter Binding Potentials in Brain of Juvenile Monkeys 1 Year After Discontinuation of a 2-Year Treatment With Fluoxetine.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Born this way: Hippocampal neurogenesis across the lifespan.Aging cell · 2019Review
- Depressive disorders: Treatment failures and poor prognosis over the last 50 years.Pharmacology research & perspectives · 2019Review
- The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux.Scientific reports · 2019Article
- Targeting Serotonin Transporters in the Treatment of Juvenile and Adolescent Depression.Frontiers in neuroscience · 2019Article
- Fluoxetine exposure in adolescent and adult female mice decreases cocaine and sucrose preference later in life.Journal of psychopharmacology (Oxford, England) · 2018Article
- Fluoxetine Inhibits Natural Decay of Long-Term Memory via Akt/GSK-3β Signaling.Molecular neurobiology · 2018Article
- Effects of Fluoxetine on Hippocampal Neurogenesis and Neuroprotection in the Model of Global Cerebral Ischemia in Rats.International journal of molecular sciences · 2018Article
- Early antipsychotic treatment in juvenile rats elicits long-term alterations to the adult serotonin receptors.Neuropsychiatric disease and treatment · 2018Article
- Dietary restriction reduces hippocampal neurogenesis and granule cell neuron density without affecting the density of mossy fibers.Brain research · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The antidepressant drug fluoxetine (Prozac) has been increasingly prescribed to children and adolescents with depressive disorders despite a lack of thorough understanding of its therapeutic effects in the paediatric population and of its putative neurodevelopmental effects. Within the framework of PRIOMEDCHILD ERA-NET, we investigated; a) effects of chronic fluoxetine treatment on adult hippocampal neurogenesis, a structural readout relevant for antidepressant action and hippocampal development; b) effects on tryptophan hydroxylase (TPH) expression, a measure of serotonin synthesis; c) whether treatment effects during adolescence differed from treatment at an adult age, and d) whether they were subregion-specific. Stereological quantification of the number of proliferating (Ki-67+) cells and of the number of young migratory neurons (doublecortin+), revealed a significant age-by-treatment interaction effect, indicating that fluoxetine affects both proliferation and neurogenesis in adolescent-treated rats differently than it does in adult-treated rats. In terms of subregional differences, fluoxetine enhanced proliferation mainly in the dorsal parts of the hippocampus, and neurogenesis in both the suprapyramidal and infrapyramidal blades of the dentate gyrus in adolescent-treated rats, while no such differences were seen in adult-treated rats. Fluoxetine exerted similar age-by-treatment interaction effects on TPH cells mainly in the ventral portion of the dorsal raphe nucleus. We conclude that fluoxetine exerts divergent effects on structural plasticity and serotonin synthesis in adolescent versus adult-treated rats. These preliminary data indicate a differential sensitivity of the adolescent brain to this drug and thus warrant further research into their behavioural and translational aspects. Together with recent related findings, they further call for caution in prescribing these drugs to the adolescent population.
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