ArticleJAMA dermatology2014
Confocal microscopy-guided laser ablation for superficial and early nodular Basal cell carcinoma: a promising surgical alternative for superficial skin cancers.
Article in JAMA dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Management of Skin Cancer in the High-Risk Patient.Current treatment options in oncology · 2016Pooled it
- Application Value of High Resolution Magnetic Resonance Imaging in Preoperative Evaluation of Non-melanoma Skin Cancer.Current medical imaging · 2025Article
- Vulvar's Paget's disease treated with a combination of clock mapping and imiquimod.Archives of gynecology and obstetrics · 2023Article
- Optical imaging guided- 'precision' biopsy of skin tumors: a novel approach for targeted sampling and histopathologic correlation.Archives of dermatological research · 2021Observational
- Speckle-free, near-infrared portable confocal microscope.Applied optics · 2020Article
- Current and future applications of confocal laser scanning microscopy imaging in skin oncology.Oncology letters · 2019Review
- Introduction to reflectance confocal microscopy and its use in clinical practice.JAAD case reports · 2018Article
- [Laser treatment of basal cell carcinoma].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Review
- Updates on the Management of Non-Melanoma Skin Cancer (NMSC).Healthcare (Basel, Switzerland) · 2017Review
- Reflectance confocal microscopy-guided laser ablation of basal cell carcinomas: initial clinical experience.Journal of biomedical optics · 2017Article
- Reflectance confocal microscopy of skin in vivo: From bench to bedside.Lasers in surgery and medicine · 2017Review
- Carbon dioxide laser ablation of basal cell carcinoma with visual guidance by reflectance confocal microscopy: a proof-of-principle pilot study.The British journal of dermatology · 2016Article
- Reflectance confocal microscopy and dermoscopy forOncology letters · 2016Article
- Confocal imaging of carbon dioxide laser-ablated basal cell carcinomas: An ex-vivo study on the uptake of contrast agent and ablation parameters.Lasers in surgery and medicine · 2016Article
- Simultaneous spatial frequency modulation imaging and micromachining with a femtosecond laser.Optics letters · 2016Article
- Differentiation of cutaneous melanoma from surrounding skin using laser-induced breakdown spectroscopy.Biomedical optics express · 2016Article
- Combined reflectance confocal microscopy-optical coherence tomography for delineation of basal cell carcinoma margins: an ex vivo study.Journal of biomedical optics · 2016Article
- [Confocal laser scanning microscopy].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2015Review
- Article
- Confocal imaging-guided laser ablation of basal cell carcinomas: an ex vivo study.The Journal of investigative dermatology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
importanceLaser ablation is a rapid and minimally invasive approach for the treatment of superficial skin cancers, but efficacy and reliability vary owing to lack of histologic margin control. High-resolution reflectance confocal microscopy (RCM) may offer a means for examining margins directly on the patient. OBSERVATIONS: We report successful elimination of superficial and early nodular basal cell carcinoma (BCC) in 2 cases using RCM imaging to guide Er:YAG laser ablation. Three-dimensional (3D) mapping is feasible with RCM to delineate the lateral border and thickness of the tumor. Thus, the surgeon may deliver laser fluence and passes with localized control-ie, by varying the ablation parameters in sublesional areas with specificity that is governed by the 3D topography of the BCC. We further demonstrate intraoperative detection of residual BCC after initial laser ablation and complete removal of remaining tumor by additional passes. Both RCM imaging and histologic sections confirm the final clearance of BCC. CONCLUSIONS AND RELEVANCE: Confocal microscopy may enhance the efficacy and reliability of laser tumor ablation. This report represents a new translational application for RCM imaging, which, when combined with an ablative laser, may one day provide an efficient and cost-effective treatment for BCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.