ArticleInternational journal of obesity (2005)2015
Association between MC4R rs17782313 polymorphism and overeating behaviors.
Article in International journal of obesity (2005), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03766191 (The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children), which is not on this map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Relation of Genetic Factors, Food Cues, and Self-Regulation With Excess Consumption and Adiposity in Children
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of MC4R rs17782313 Genotype With Energy Intake and Appetite: A Systematic Review and Meta-analysis.Nutrition reviews · 2025Pooled it
- Dietary Protein Modifies the Effect of theThe Journal of nutrition · 2017Trial
- In Vivo Gastric Expression of FTO and MC4R in Sleeve Gastrectomy Patients: Diagnostic Utility Without Predictive Value for Weight Loss.Obesity surgery · 2026Article
- Parallel Pathways, Divergent Outcomes: Adipose Tissue-Neural Crosstalk in Depression and Obesity.Journal of clinical medicine · 2025Review
- Understanding food addiction in obesity: a genetic perspective.Journal of eating disorders · 2025Article
- Sweet Taste Receptors' Genetic Variability in Advanced Potential Targets of Obesity.Nutrients · 2025Article
- The melanocortin receptor genes are linked to and associated with the risk of polycystic ovary syndrome in Italian families.Journal of ovarian research · 2024Article
- Association of the rs17782313, rs17773430 and rs34114122 Polymorphisms of/nearChildren (Basel, Switzerland) · 2023Article
- Interaction of fatty acid quality indices and genes related to lipid homeostasis on mental health among overweight and obese women.Scientific reports · 2023Article
- The interaction between MC4R gene variant (rs17782313) and dominant dietary patterns on depression in obese and overweight women: a cross sectional study.BMC endocrine disorders · 2023Article
- Relationship between a near Melanocortin-4 receptor gene variant and puberty timing in children is vague unlike obesity.Journal of diabetes and metabolic disorders · 2022Article
- Association and interaction of the MC4R rs17782313 polymorphism with plasma ghrelin, GLP-1, cortisol, food intake and eating behaviors in overweight/obese Iranian adults.BMC endocrine disorders · 2022Article
- Implication of Melanocortin Receptor Genes in the Familial Comorbidity of Type 2 Diabetes and Depression.International journal of molecular sciences · 2022Article
- Association of the MC4R rs17782313 polymorphism with plasma ghrelin, leptin, IL6 and TNFα concentrations, food intake and eating behaviors in morbidly obese women.Eating and weight disorders : EWD · 2021Article
- Review
- A systematic review on different models of inducing obesity in animals: Advantages and limitations.Journal of advanced veterinary and animal research · 2020Review
- Article
- The Role of Genetic Variation of BMI, Body Composition, and Fat Distribution for Mental Traits and Disorders: A Look-Up and Mendelian Randomization Study.Frontiers in genetics · 2020Article
- Evaluation ofOman medical journal · 2019Article
- Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children.Endocrine · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND/
objectivesMelanocortins have a crucial role in appetite and weight regulation. Although the melanocortin 4 receptor (MC4R) gene has been repeatedly linked to obesity and antipsychotic-induced weight gain, the mechanism behind how it leads to this effect in still undetermined. The goal of this study was to conduct an in-depth and sophisticated analysis of MC4R polymorphisms, body mass index (BMI), eating behavior and depressed mood. SUBJECTS/
methodsWe genotyped 328 individuals of European ancestry on the following MC4R markers based on the relevant literature on obesity and antipsychotic-induced weight gain: rs571312, rs17782313, rs489693, rs11872992, and rs8087522. Height and weight were measured, and information on depressed mood and overeating behaviors was obtained during the in-person assessment.
resultsBMI was associated with rs17782313 C allele; however, this finding did not survive correction for multiple testing (P = 0.018). Although rs17782313 was significantly associated with depressed mood and overeating behaviors, tests of indirect effects indicated that emotional eating and food cravings, rather than depressed mood, uniquely accounted for the effect of this marker and BMI (n = 152).
conclusionsTo our knowledge, this is the first study to investigate the link between MC4R rs17782313, mood and overeating behavior, as well as to demonstrate possible mechanisms behind MC4R's influence on body weight. If replicated in a larger sample, these results may have important clinical implications, including potential for the use of MC4R agonists in the treatment of obesity and disordered eating.
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