ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2014
Effects of anesthesia with isoflurane, ketamine, or propofol on physiologic parameters in neonatal rhesus macaques (Macaca mulatta).
Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Case Report: From critical trauma to functional recovery: a novel surgical and hand-rearing strategy in a neonatal Hamadryas baboon (Frontiers in veterinary science · 2026Article
- Total Intravenous Anesthesia with Propofol Effectively Provides a Light Anesthesia Plane in Cynomolgus Male Monkeys (Macaca fascicularis) Undergoing Nociceptive Heat Stimulation.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
- Remotely controlled drug release in deep brain regions of non-human primates.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Effects of Anesthesia on Cerebral Blood Flow and Functional Connectivity of Nonhuman Primates.Veterinary sciences · 2022Review
- Performance of Marmoset Monkeys as Embryo Donors Is Reflected by Different Stress-Related Parameters.Animals : an open access journal from MDPI · 2022Article
- Neurocardiovascular coupling in congenital diaphragmatic hernia patients undergoing different types of surgical treatment.European journal of anaesthesiology · 2022Observational
- Astrogliosis in juvenile non-human primates 2 years after infant anaesthesia exposure.British journal of anaesthesia · 2021Article
- Effects of alfaxalone on cerebral blood flow and intrinsic neural activity of rhesus monkeys: A comparison study with ketamine.Magnetic resonance imaging · 2021Article
- Optimizing Auditory Brainstem Response Acquisition Using Interleaved Frequencies.Journal of the Association for Research in Otolaryngology : JARO · 2020Article
- Mitochondrial Oxygen Monitoring During Surgical Repair of Congenital Diaphragmatic Hernia or Esophageal Atresia: A Feasibility Study.Frontiers in pediatrics · 2020Article
- Effect of different anesthetic mixtures-ketamine-xylazine, ketamine-acepromazine and tiletamine-zolazepam-on the physiological and blood biochemistry parameters of male rhesus monkeys (Animal models and experimental medicine · 2019Article
- Exposure of Developing Brain to General Anesthesia: What Is the Animal Evidence?Anesthesiology · 2018Review
- Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques.Anesthesiology · 2017Article
- Use of nonhuman primates for the development of bioengineered female reproductive organs.Tissue engineering and regenerative medicine · 2016Article
- Cardiopulmonary effects of thiopental versus propofol as an induction agent prior to isoflurane anesthesia in chair trained rhesus macaques (Macaca mulatta).Laboratory animal research · 2016Article
- The genetics of isoflurane-induced developmental neurotoxicity.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Isoflurane, ketamine, and propofol are common anesthetics in human and nonhuman primate medicine. However, scant normative data exist regarding the response of neonatal macaques to these anesthetics. We compared the effects of isoflurane, ketamine, and propofol anesthesia on physiologic parameters in neonatal rhesus macaques. Neonatal rhesus macaques (age, 5 to 7 d) were exposed to isoflurane (n = 5), ketamine (n = 4), propofol (n = 4) or no anesthesia (n = 5) for 5 h. The anesthetics were titrated to achieve a moderate anesthetic plane, and heart rate, blood pressure, respiratory rate, end tidal carbon dioxide, oxygen saturation, and temperature were measured every 15 min. Venous blood samples were collected to determine blood gases and metabolic status at baseline, 0.5, 2.5, and 4.5 h after induction and at 3 h after the end of anesthesia. Compared with ketamine, isoflurane caused more hypotensive events and necessitated the administration of increased volumes of intravenous fluids to support blood pressure throughout anesthesia; no significant differences were observed between the isoflurane and propofol groups for these parameters. In addition, isoflurane resulted in a significantly shorter average time to extubation, compared with both ketamine and propofol. Due to supportive care, other physiologic variables remained stable between anesthetic regimens and throughout the 5-h exposure. These data improve our understanding of the effects of these 3 anesthetics in neonatal rhesus macaques and will aid veterinarians and researchers as they consider the risks and benefits of and resources required during general anesthesia in these animals.
Indexed as
Identifiers
24827572PMC4128568W1456730919What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.