ArticleProceedings. Biological sciences2014
Adaptive phylogeography: functional divergence between haemoglobins derived from different glacial refugia in the bank vole.
Article in Proceedings. Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Chromosome-level genome of the bank vole (Clethrionomys glareolus): a resource for eco-evo-disease research.Scientific data · 2026Article
- Genomic signatures of rapid local selection and introgression drive adaptive phylogeography in the European river skater.BMC biology · 2026Article
- Beyond the laboratory: the bank vole (Clethrionomys glareolus) as a novel model organism in biological research.Frontiers in zoology · 2025Review
- Genetic admixture drives climate adaptation in the bank vole.Communications biology · 2024Article
- Local adaptation and future climate vulnerability in a wild rodent.Nature communications · 2023Article
- Different waves of postglacial recolonisation and genomic structure of bank vole populations in NE Poland.Heredity · 2023Article
- Genic distribution modelling predicts adaptation of the bank vole to climate change.Communications biology · 2022Article
- A dynamic history of admixture from Mediterranean and Carpathian glacial refugia drives genomic diversity in the bank vole.Ecology and evolution · 2021Article
- Niche differentiation in a postglacial colonizer, the bank voleEcology and evolution · 2021Article
- Article
- Profiling of the TCRβ repertoire in non-model species using high-throughput sequencing.Scientific reports · 2018Article
- Genomics of end-Pleistocene population replacement in a small mammal.Proceedings. Biological sciences · 2018Article
- Article
- Mammalian Comparative Genomics Reveals Genetic and Epigenetic Features Associated with Genome Reshuffling in Rodentia.Genome biology and evolution · 2016Article
- The colonization history of British water vole (Arvicola amphibius (Linnaeus, 1758)): origins and development of the Celtic fringe.Proceedings. Biological sciences · 2016Article
- Mapping 3' transcript ends in the bank vole (Clethrionomys glareolus) mitochondrial genome with RNA-Seq.BMC genomics · 2015Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the years, researchers have used presumptively neutral molecular variation to infer the origins of current species' distributions in northern latitudes (especially Europe). However, several reported examples of genic and chromosomal replacements suggest that end-glacial colonizations of particular northern areas may have involved genetic input from different source populations at different times, coupled with competition and selection. We investigate the functional consequences of differences between two bank vole (Clethrionomys glareolus) haemoglobins deriving from different glacial refugia, one of which partially replaced the other in Britain during end-glacial climate warming. This allows us to examine their adaptive divergence and hence a possible role of selection in the replacement. We determine the amino acid substitution Ser52Cys in the major expressed β-globin gene as the allelic difference. We use structural modelling to reveal that the protein environment renders the 52Cys thiol a highly reactive functional group and we show its reactivity in vitro. We demonstrate that possessing the reactive thiol in haemoglobin increases the resistance of bank vole erythrocytes to oxidative stress. Our study thus provides striking evidence for physiological differences between products of genic variants that spread at the expense of one another during colonization of an area from different glacial refugia.
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