ArticlePediatric cardiology2014
Latent rheumatic heart disease: outcomes 2 years after echocardiographic detection.
Article in Pediatric cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03346525 (The GOAL), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The GOAL (GwokO Adunu pa Lutino) Trial: Determining the Impact of Penicillin on Latent Rheumatic Heart Disease: A Randomized Controlled Trial in Uganda
Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Pooled it
- The burden of rheumatic heart disease and issues affecting the provision of care in Malawi: A scoping review.PLoS neglected tropical diseases · 2025Article
- 2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease.Nature reviews. Cardiology · 2024Review
- The Echocardiographic Diagnosis of Rheumatic Heart Disease: A Review of the Performance of the World Heart Federation Criteria 2012-2023.Global heart · 2024Review
- Detection and management of latent rheumatic heart disease: a narrative review.Annals of medicine and surgery (2012) · 2023Review
- Rheumatic Heart Disease in the Developing World.Structural heart : the journal of the Heart Team · 2023Review
- Comparison of approaches to determine echocardiographic outcomes for children with latent rheumatic heart disease.Open heart · 2022Article
- Screening for subclinical rheumatic heart disease: addressing borderline disease in a real-world setting.European heart journal open · 2021Article
- Article
- Echocardiography Screening for Latent Rheumatic Heart Disease: What Can We Do in Indonesia?Frontiers in surgery · 2020Article
- Decreased Prevalence of Rheumatic Heart Disease Confirmed Among HIV-positive Youth.The Pediatric infectious disease journal · 2019Article
- Prevalence of rheumatic heart disease in Zambian school children.BMC cardiovascular disorders · 2018Observational
- Task sharing to improve the prevention, diagnosis and management of rheumatic heart disease: a systematic review protocol.BMJ open · 2018Article
- Latent Rheumatic Heart Disease: Identifying the Children at Highest Risk of Unfavorable Outcome.Circulation · 2017Article
- Screening for rheumatic heart disease: is a paradigm shift required?Echo research and practice · 2017Review
- Group A Streptococcus, Acute Rheumatic Fever and Rheumatic Heart Disease: Epidemiology and Clinical Considerations.Current treatment options in cardiovascular medicine · 2017 · on this mapReview
- Targeted Echocardiographic Screening for Latent Rheumatic Heart Disease in Northern Uganda: Evaluating Familial Risk Following Identification of an Index Case.PLoS neglected tropical diseases · 2016Article
- The natural history of latent rheumatic heart disease in a 5 year follow-up study: a prospective observational study.BMC cardiovascular disorders · 2016Observational
- Brief Report: Prevalence of Latent Rheumatic Heart Disease Among HIV-Infected Children in Kampala, Uganda.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Acute rheumatic fever and rheumatic heart disease.Nature reviews. Disease primers · 2016 · on this mapReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Screening with portable echocardiography has uncovered a large burden of latent rheumatic heart disease (RHD) among asymptomatic children in endemic regions, the significance of which remains unclear. This study aimed to determine the 2-year outcomes for children with latent RHD diagnosed by echocardiographic screening. Children identified with latent RHD enrolled in a biannual follow-up program. Risk factors for disease persistence and progression were examined. Of 62 children, 51 (82 %) with latent RHD had a median follow-up period of 25 months. Of these 51 children, 17 (33.3 %) reported an interval sore throat or symptoms consistent with acute rheumatic fever (ARF). Of 43 children initially classified as having borderline RHD, 21 (49 %) remained stable, 18 (42 %) improved (to no RHD) and 4 (10 %) worsened to definite RHD. Of the 8 children initially classified as having definite RHD, 6 (75 %) remained stable, and 2 (25 %) improved to borderline RHD. Two children had confirmed episodes of recurrent ARF, one of which represented the sole case of clinical worsening. The risk factors for disease persistence or progression included younger age (p = 0.05), higher antistreptolysin O titers at diagnosis (p = 0.05), and more morphologic valve abnormalities (p = 0.01). After 2 years, most of the children had a benign course, with 91 % remaining stable or showing improvement. Education may improve recognition of streptococcal sore throat. Longer-term follow-up evaluation, however, is warranted to confirm disease progression and risk factor profile. This could help tailor screening protocols for those at highest risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.