ArticleEvolution; international journal of organic evolution2014
Spontaneous mutation accumulation in multiple strains of the green alga, Chlamydomonas reinhardtii.
Article in Evolution; international journal of organic evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Stabilizing and directional selection shape the genetic variation of gene expression in the transcriptome of Chlamydomonas.Molecular biology and evolution · 2026Article
- Pan-microalgal dark proteome mapping via interpretable deep learning and synthetic chimeras.Patterns (New York, N.Y.) · 2025Article
- Review
- The Effects of De Novo Mutation on Gene Expression and the Consequences for Fitness in Chlamydomonas reinhardtii.Molecular biology and evolution · 2024Article
- Rates and spectra of de novo structural mutations inGenome research · 2023Article
- The distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii inferred using frequency changes under experimental evolution.PLoS genetics · 2022Article
- Fitness Effects of Mutations: An Assessment of PROVEAN Predictions Using Mutation Accumulation Data.Genome biology and evolution · 2022Article
- De Novo Mutation Rate Variation and Its Determinants in Chlamydomonas.Molecular biology and evolution · 2021Article
- The insect-killing bacteriumMarine life science & technology · 2021Article
- Inferring the distribution of fitness effects of spontaneous mutations in Chlamydomonas reinhardtii.PLoS biology · 2019Article
- Temperature responses of mutation rate and mutational spectrum in an Escherichia coli strain and the correlation with metabolic rate.BMC evolutionary biology · 2018Article
- Rates and Patterns of Mutation in Tandem Repetitive DNA in Six Independent Lineages of Chlamydomonas reinhardtii.Genome biology and evolution · 2018Article
- Quantifying natural seasonal variation in mutation parameters with mutation accumulation lines.Ecology and evolution · 2018Article
- Fitness change in relation to mutation number in spontaneous mutation accumulation lines of Chlamydomonas reinhardtii.Evolution; international journal of organic evolution · 2017Article
- Spontaneous Mutation Rate in the Smallest Photosynthetic Eukaryotes.Molecular biology and evolution · 2017Article
- Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae.G3 (Bethesda, Md.) · 2016Article
- Antibiotic treatment enhances the genome-wide mutation rate of target cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Fitness effects of new mutations in Chlamydomonas reinhardtii across two stress gradients.Journal of evolutionary biology · 2016Article
- Extensive de novo mutation rate variation between individuals and across the genome of Chlamydomonas reinhardtii.Genome research · 2015Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Estimates of mutational parameters, such as the average fitness effect of a new mutation and the rate at which new genetic variation for fitness is created by mutation, are important for the understanding of many biological processes. However, the causes of interspecific variation in mutational parameters and the extent to which they vary within species remain largely unknown. We maintained multiple strains of the unicellular eukaryote Chlamydomonas reinhardtii, for approximately 1000 generations under relaxed selection by transferring a single cell every ~10 generations. Mean fitness of the lines tended to decline with generations of mutation accumulation whereas mutational variance increased. We did not find any evidence for differences among strains in any of the mutational parameters estimated. The overall change in mean fitness per cell division and rate of input of mutational variance per cell division were more similar to values observed in multicellular organisms than to those in other single-celled microbes. However, after taking into account differences in genome size among species, estimates from multicellular organisms and microbes, including our new estimates from C. reinhardtii, become substantially more similar. Thus, we suggest that variation in genome size is an important determinant of interspecific variation in mutational parameters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.