Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer.

Susanne Schüler, Claus Lattrich, Maciej Skrzypczak, Tanja Fehm, Olaf Ortmann, Oliver Treeck

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Article in Journal of ovarian research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.3field-weighted citation impact, top 38% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 3 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Susanne SchülerDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany.

Claus LattrichDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany.

Maciej SkrzypczakSecond Department of Gynecology, Medical University of Lublin, Lublin, Poland.

Tanja FehmDepartment of Gynecology and Obstetrics, University of Tübingen, Tübingen, Germany.

Olaf OrtmannDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany.

Oliver TreeckDepartment of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany.

University Hospital Regensburg · DEMedical University of Lublin · PLUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with ovarian cancer susceptibility. For this purpose, we compared the genotype and allele frequencies of the SNPs rs1467465 and rs12048235 in a group of 184 ovarian cancer patients with a control group of 184 age- and gender-matched women without any malignancy. Genotype-phenotype association revealed that A allele of SNP rs1467465 was more frequent in ovarian cancer patients than in the control group (0.40 vs. 0.33, OR 1.37, 95% CI 1.013-1.853, p = 0.04). After analysis of allele positivity we observed that A-positive genotypes were more frequent in the ovarian cancer group (0.65 vs. 0.53, OR 1.63, 95% CI 1.072-2.483, p = 0.02). Furthermore, the heterozygous genotype of rs1467465 was found to be more frequent in the patients group (0.50 vs. 0.41, OR 1.63, 95% CI 1.045-2.045, p = 0.03). No significant results were obtained with regard to SNP rs1204823. Our data suggest, that SNP rs1467465 of human gene icb-1 might affect susceptibility to ovarian cancer.

Indexed as

Polymorphism, Single NucleotideCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHumansIntracellular Signaling Peptides and ProteinsMiddle AgedNeoplasm ProteinsNeoplasms, Cystic, Mucinous, and SerousOvarian NeoplasmsRisk FactorsSequence Analysis, DNAIntracellular Signaling Peptides and ProteinsNeoplasm ProteinsTHEMIS2 protein, humanCase control studyicb-1 geneOvarian cancerSingle nucleotide polymorphism

Identifiers

PMID24826199

DOI10.1186/1757-2215-7-42

PMCPMC4018944

OpenAlexW2136530838

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.