Evidence map›Paper›PMID 24825953›Full record

ArticleBehavioural neurology2014

Patients with mild cognitive impairment display reduced auditory event-related delta oscillatory responses.

Pınar Kurt, Derya Durusu Emek-Savaş, Kübra Batum, Bilge Turp, Bahar Güntekin, Sibel Karşıdağ, Görsev Gülmen Yener

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Machine learning based on event-related oscillations of working memory differentiates between preclinical Alzheimer's disease and normal aging.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pınar KurtBrain Dynamics and Multidisciplinary Research Center, Dokuz Eylul University, Balçova, 35340 Izmir, Turkey ; Department of Neurosciences, Dokuz Eylul University, 35340 Izmir, Turkey ; Department of Neurology, Dokuz Eylul University, 35340 Izmir, Turkey ; Department of Psychology, Istanbul Arel University, 34295 Istanbul, Turkey.
Derya Durusu Emek-SavaşBrain Dynamics and Multidisciplinary Research Center, Dokuz Eylul University, Balçova, 35340 Izmir, Turkey ; Department of Neurosciences, Dokuz Eylul University, 35340 Izmir, Turkey ; Brain Dynamics, Cognition and Complex Systems Research Center Istanbul Kültür University, 35156 Istanbul, Turkey.
Kübra BatumDepartment of Neurology, Maltepe University, 34844 Istanbul, Turkey.
Bilge TurpBrain Dynamics, Cognition and Complex Systems Research Center Istanbul Kültür University, 35156 Istanbul, Turkey.
Bahar GüntekinBrain Dynamics, Cognition and Complex Systems Research Center Istanbul Kültür University, 35156 Istanbul, Turkey.
Sibel KarşıdağDepartment of Neurology, Maltepe University, 34844 Istanbul, Turkey.
Görsev Gülmen YenerBrain Dynamics and Multidisciplinary Research Center, Dokuz Eylul University, Balçova, 35340 Izmir, Turkey ; Department of Neurosciences, Dokuz Eylul University, 35340 Izmir, Turkey ; Department of Neurology, Dokuz Eylul University, 35340 Izmir, Turkey ; Brain Dynamics, Cognition and Complex Systems Research Center Istanbul Kültür University, 35156 Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvent-related oscillations (ERO) may provide a useful tool for the identification of cognitive deficits in mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we investigate peak-to-peak amplitude of auditory event-related delta oscillations of MCI subjects.

methodThe study included twenty-two consecutive patients with MCI recruited in neurology clinic and 21 age- and education-matched normal elderly controls. A classical auditory oddball paradigm was used in the experiments. EEG was recorded from F3, Fz, F4, C3, Cz, C4, P3, Pz, P4, O1, Oz, and O2 locations. The maximum peak-to-peak amplitudes for each subject's averaged delta response (0.5-2.2 Hz) were measured.

resultsThe amplitudes between groups differed significantly at the frontal and mid-centroparietal locations. ANOVA on delta responses revealed a significant effect for groups (F(1.41) = 4.84, P = 0.033), indicating a larger delta response for healthy controls than MCI subjects. Post hoc comparisons revealed that peak-to-peak delta response was significantly larger for healthy controls than for MCI over electrode sites F3, Fz, F4, Cz, C4, and Pz. DISCUSSION: Event-related delta frequency band seems to be the most affected oscillatory response in cognitive impairment due to AD. Therefore, it deserves to be investigated as a candidate electrophysiological biomarker in further studies.

Indexed as

AgedAged, 80 and overAuditory CortexCognitive DysfunctionDelta RhythmElectroencephalographyEvoked Potentials, AuditoryFemaleHumansMaleMiddle Aged

Identifiers

PMID24825953
PMCPMC4006610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.