Evidence map›Paper›PMID 24825739›Full record

ArticleBirth (Berkeley, Calif.)2014

What women want: lead considerations for current and future applications of noninvasive prenatal testing in prenatal care.

Ruth M Farrell, Patricia K Agatisa, Benjamin Nutter

Open access · greenAbstract read
In one paragraph

Article in Birth (Berkeley, Calif.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
11.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Attitudes About NIPT Routinisation: A Report from a Qualitative Study of 20 UK Healthcare Professionals.Health care analysis : HCA : journal of health philosophy and policy · 2026
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  19. Preferences for prenatal diagnosis of sickle-cell disorder: A discrete choice experiment comparing potential service users and health-care providers.Health expectations : an international journal of public participation in health care and health policy · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ruth M FarrellDepartment of Bioethics, Cleveland Clinic, Cleveland, OH, USA; Department of Obstetrics & Gynecology, Cleveland Clinic, Cleveland, OH, USA; Department of Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
Patricia K Agatisa
Benjamin Nutter
Cleveland Clinic · US

Funding

Case Western Reserve University/Cleveland Clinic CTSA (KL2)KL2RR024990 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$9.5M
NCRR NIH HHS KL2 RR024990
6 · The paper itself

Abstract

backgroundNoninvasive prenatal testing (NIPT) will change the delivery of prenatal care for all women, including those considered low risk for fetal chromosomal abnormalities. This study investigated pregnant women's attitudes, informational needs, and decision-making preferences with respect to current and future applications of NIPT.

methodsA survey instrument was used to identify aspects of the decision-making process for NIPT among low-risk and high-risk populations.

resultsBoth low-risk and high-risk women (n = 334) expressed interest in incorporating NIPT as a screening test into their prenatal care. Information specific to NIPT's detection rate (86%), indications (77%), and performance in comparison with conventional screens and diagnostic tests (63%) were identified as lead factors when considering its use. The future availability of NIPT as a diagnostic test increased women's willingness to undergo testing for fetal aneuploidy, cancer susceptibility, and childhood-onset and adult-onset diseases. Despite its noninvasive aspects, participants expressed the need for a formal informed consent process (71%) to take place before testing.

conclusionsThis study demonstrates that NIPT will introduce new challenges for pregnant women and their health care practitioners who will be charged with supporting informed decision making about its use. It is critical that obstetric professionals are prepared to facilitate a patient-centered decision-making process as its clinical application rapidly changes.

Indexed as

Decision MakingAdultAneuploidyCross-Sectional StudiesFemaleForecastingGenetic TestingHealth Knowledge, Attitudes, PracticeHumansInformed ConsentPregnancyPrenatal CarePrenatal DiagnosisSurveys and QuestionnairesYoung Adultinformed consentmaternal decision makingprenatal genetic testing

Identifiers

PMID24825739
PMCPMC4195446
OpenAlexW2159406409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.