ArticleTransplantation2014
Expansion and somatic hypermutation of B-cell clones in rejected human kidney grafts.
Article in Transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- The effects of intragraft CD38+ B cell on chronic active antibody mediated rejection in kidney transplantation.International urology and nephrology · 2025Article
- Clinical application of immune repertoire sequencing in solid organ transplant.Frontiers in immunology · 2023Review
- Article
- Presence of intragraft B cells during acute renal allograft rejection is accompanied by changes in peripheral blood B cell subsets.Clinical and experimental immunology · 2019Article
- Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing.Nature communications · 2019Article
- T Follicular Regulatory Cells and Antibody Responses in Transplantation.Transplantation · 2018Review
- New insights on innate B-cell immunity in transplantation.Xenotransplantation · 2018Review
- Targeting B Cells and Plasma Cells in Glomerular Diseases: Translational Perspectives.Journal of the American Society of Nephrology : JASN · 2018Review
- T Cells That Help B Cells in Chronically Inflamed Tissues.Frontiers in immunology · 2018Review
- Dynamics of B Cell Recovery In Kidney/Bone Marrow Transplant Recipients.Transplantation · 2017Article
- B lymphocytes in renal interstitial fibrosis.Journal of cell communication and signaling · 2017Review
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundB-cell infiltrates are common in rejected kidney allografts, yet their composition is still unclear. The aim of our study was to characterize the clonal composition of B-cell infiltrates of rejected human kidney grafts.
methodsWe used a molecular approach to characterize the partial B-cell repertoires of 5 failed human kidney grafts with detectable B-cell infiltrates. A comparison between the intragraft and blood repertoire was also conducted for 1 case.
resultsRedundant sequences were observed in both blood and graft, although the level of clonal amplification was significantly higher for the graft. Somatic hypermutations (SHMs) were also more frequent in sequences found in the graft compared to the blood. The rate of nonsilent mutations was significantly higher in complementarity determining regions (CDRs) compared to framework regions in blood sequences as well as in graft sequences found at low frequency. In contrast, this preferential distribution was lost in sequences found at high frequency in the graft, suggesting a lack of affinity maturation in situ. Lastly, follicular dendritic cells were undetectable in CD20 infiltrates in all samples examined.
conclusionsWe provide here evidence that B-cell clones expand and undergo SHMs in situ. However, the even distribution of nonsilent SHM in high-frequency graft sequences together with the absence of follicular dendritic cells do not support the view that infiltrating B cells are part of functional germinal centers.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.