ArticleAngewandte Chemie (International ed. in English)2014
Synthesis of tetrahydropyran/tetrahydrofuran-containing macrolides by palladium-catalyzed alkoxycarbonylative macrolactonizations.
Article in Angewandte Chemie (International ed. in English), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 52 citations in OpenAlex.
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- Convergent and Efficient Total Synthesis of (+)-Heilonine Enabled by C-H Functionalizations.Journal of the American Chemical Society · 2024Article
- Palladium-Catalyzed Carbonylations: Application in Complex Natural Product Total Synthesis and Recent Developments.The Journal of organic chemistry · 2023Review
- Neopeltolide and its synthetic derivatives: a promising new class of anticancer agents.Frontiers in pharmacology · 2023Review
- Metal-free visible-light-promoted C(spGreen chemistry : an international journal and green chemistry resource : GC · 2021Article
- Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation.The Journal of antibiotics · 2019Article
- Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids.Journal of the American Chemical Society · 2018Article
- Rapid synthesis of bicyclic lactones via palladium-catalyzed aminocarbonylative lactonizations.Chemical communications (Cambridge, England) · 2017Article
- Diastereoselective Synthesis of Highly Substituted Tetrahydrofurans by Pd-Catalyzed Tandem Oxidative Cyclization-Redox Relay Reactions Controlled by Intramolecular Hydrogen Bonding.The Journal of organic chemistry · 2017Article
- Total Synthesis of (-)-Spinosyn A via Carbonylative Macrolactonization.Journal of the American Chemical Society · 2016Article
- Catalytic Carbonylative Spirolactonization of Hydroxycyclopropanols.Journal of the American Chemical Society · 2016Article
- Contemporary Strategies for the Synthesis of Tetrahydropyran Derivatives: Application to Total Synthesis of Neopeltolide, a Marine Macrolide Natural Product.Marine drugs · 2016Review
- Total Synthesis and Structural Reassignment of Lyngbyaloside C Highlighted by Intermolecular Ketene Esterification.Chemistry (Weinheim an der Bergstrasse, Germany) · 2015Article
- Exo-selective reductive macrocyclization of ynals.Organic letters · 2015Article
- Strategies and Methods for the Synthesis of Anticancer Natural Product Neopeltolide and its Analogs.Current organic chemistryArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A novel Pd-catalyzed cascade alkoxycarbonylative macrolactonization to construct tetrahydropyran/tetrahydrofuran-containing bridged macrolactones in one step from alkendiols is described. Products with various ring sizes and substituents were obtained. Challenging macrolactones involving tertiary alcohols were synthesized smoothly as well. Mechanistically, experimental evidence to support a trans-oxypalladation step has been provided. The method was applied to the synthesis of potent anticancer compound 9-demethylneopeltolide.
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