Evidence map›Paper›PMID 24825060›Full record

ArticleThe Journal of investigative dermatology2014

Calcium, Orai1, and epidermal proliferation.

Daniel D Bikle, Theodora M Mauro

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Daniel D BikleEndocrine Research Unit, Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, California, USA.
Theodora M MauroDermatology Research Unit, Department of Dermatology, VA Medical Center, University of California, San Francisco, San Francisco, California, USA. Electronic address: maurot@derm.ucsf.edu.
San Francisco VA Medical Center · US

Funding

Vitamin D Receptor Coactivators in KeratinocytesR01AR050023 · NIAMS · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI BIKLE, DANIEL DAVID · 2004 to 2014
$3.4M
ATP2A2-Regulated Keretinocyted Ca2+ Signaling MechanismsR01AR051930 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2006 to 2019
$3.2M
Aging Stratum Corneum pH and Barrier FunctionR01AG028492 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2008 to 2012
$1.5M
The Lipid and Tight Junction Epidermal Barriers are InterdependentR21AR061583 · NIAMS · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MAURO, THEODORA M · 2012 to 2013
$358k
Role of vitamin D and calcium signaling in wound healingI01BX001066 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 2011 to 2014
–
BLRD VA I01 BX001066NIAMS NIH HHS R01 AR050023NIAMS NIH HHS R01 AR051930NIAMS NIH HHS R01AR051930NIAMS NIH HHS R21 AR061583NIA NIH HHS R01 AG028492NIA NIH HHS R01AG028492
6 · The paper itself

Abstract

Ca(2+) influx controls essential epidermal functions, including proliferation, differentiation, cell migration, itch, and barrier homeostasis. The Orai1 ion channel allows capacitive Ca(2+) influx after Ca(2+) release from the endoplasmic reticulum, and it has now been shown to modulate epidermal atrophy. These findings reveal new interactions among various Ca(2+) signaling pathways and uncover novel functions for Ca(2+) signaling via the Orai1 channel.

Indexed as

Calcium SignalingAnimalsCalcium ChannelsEpidermisHumansORAI1 ProteinCalcium ChannelsORAI1 ProteinORAI1 protein, humanOrai1 protein, mouse

Identifiers

PMID24825060
PMCPMC4023905
OpenAlexW2077475214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.