Evidence map›Paper›PMID 24824770›Full record

Trial reportMedicine and science in sports and exercise2015

Aerobic exercise and attention deficit hyperactivity disorder: brain research.

Jae Won Choi, Doug Hyun Han, Kyung Doo Kang, Hye Yeon Jung, Perry F Renshaw

3 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine and science in sports and exercise, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 52 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 20 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03666416 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Acute Effects of Exercise in College Students With ADHD

TypeinterventionalSponsorUniversity of WyomingRan2018 to 2025Enrolled48ConditionsAttention Deficit Hyperactivity Disorder, Effects of, Exertion, Working MemoryArmsSprint Interval Training
NCT05308758 nacompletednot on this mapstarted 2021, after this paper: background citation

Effect of Game-based High-Intensity Interval Training Program on the Executive Function of Children With ADHD: Protocol of A Randomized Controlled Trial

TypeinterventionalSponsorEducation University of Hong KongRan2021 to 2024Enrolled47ConditionsAdhd Deficits in Attention Motor Control and PerceptionArmsGame-based High-Intensity Interval Training, GameSAE
NCT06134557 unknown statusnot on this mapstarted 2023, after this paper: background citation

Analysis of the Therapeutic Effect of Blood Flow Reconstruction in the Treatment of Intracranial Dissection Aneurysm of Vertebral Artery

TypeobservationalSponsorQilu Hospital of Shandong UniversityRan2023 to 2024Enrolled200ConditionsIntracranial AneurysmArmsconventional stents
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 20 syntheses or guidelines pooled it, 114 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jae Won Choi1Department of Sports, Chung-Ang University, Anseong, REPUBLIC OF KOREA; 2Department of Psychiatry, Chung-Ang University Hospital, Seoul, REPUBLIC OF KOREA; and 3Brain Institute, Department of Psychiatry, University of Utah, Salt Lake City, UT.
Doug Hyun Han
Kyung Doo Kang
Hye Yeon Jung
Perry F Renshaw
Chung-Ang University · KRChung-Ang University Hospital · KRUniversity of Utah · US

Funding

Mentoring in Drug Abuse NeuroimagingK05DA031247 · NIDA · UNIVERSITY OF UTAH · PI RENSHAW, PERRY FRANKLIN · 2011 to 2015
$661k
NIDA NIH HHS K05 DA031247
6 · The paper itself

Abstract

purposeAs adjuvant therapy for enhancing the effects of stimulants and thereby minimizing medication doses, we hypothesized that aerobic exercise might be an effective adjunctive therapy for enhancing the effects of methylphenidate on the clinical symptoms, cognitive function, and brain activity of adolescents with attention deficit hyperactivity disorder (ADHD).

methodsThirty-five adolescents with ADHD were randomly assigned to one of two groups in a 1/1 ratio; methylphenidate treatment + 6-wk exercise (sports-ADHD) or methylphenidate treatment + 6-wk education (edu-ADHD). At baseline and after 6 wk of treatment, symptoms of ADHD, cognitive function, and brain activity were evaluated using the Dupaul attention deficit hyperactivity disorder rating scale--Korean version (K-ARS), the Wisconsin Card Sorting Test, and 3-T functional magnetic resonance imaging, respectively.

resultsThe K-ARS total score and perseverative errors in the sports-ADHD group decreased compared with those in the edu-ADHD group. After the 6-wk treatment period, the mean β value of the right frontal lobe in the sports-ADHD group increased compared with that in the edu-ADHD group. The mean β value of the right temporal lobe in the sports-ADHD group decreased. However, the mean β value of the right temporal lobe in the edu-ADHD group did not change. The change in activity within the right prefrontal cortex in all adolescents with ADHD was negatively correlated with the change in K-ARS scores and perseverative errors.

conclusionsThe current results indicate that aerobic exercise increased the effectiveness of methylphenidate on clinical symptoms, perseverative errors, and brain activity within the right frontal and temporal cortices in response to the Wisconsin card sorting test stimulation.

Indexed as

CognitionAdolescentAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsExerciseHumansMagnetic Resonance ImagingMaleMethylphenidateNeuropsychological TestsPatient Education as TopicPrefrontal CortexTemporal LobeCentral Nervous System StimulantsMethylphenidate

Identifiers

PMID24824770
PMCPMC5504911
OpenAlexW2083003378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.