ArticleSurgical infections2014
Association of excessive duration of antibiotic therapy for intra-abdominal infection with subsequent extra-abdominal infection and death: a study of 2,552 consecutive infections.
Article in Surgical infections, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Antibiotic Therapy of 3 Days May Be Sufficient After Biliary Drainage for Acute Cholangitis: A Systematic Review.Digestive diseases and sciences · 2021Pooled it
- [S3 Guideline Sepsis-prevention, diagnosis, therapy, and aftercare : Long version].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2020Guideline
- The 2018 Lebanese Society of Infectious Diseases and Clinical Microbiology Guidelines for the use of antimicrobial therapy in complicated intra-abdominal infections in the era of antimicrobial resistance.BMC infectious diseases · 2019Guideline
- Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.Intensive care medicine · 2017Guideline
- Trial of short-course antimicrobial therapy for intraabdominal infection.The New England journal of medicine · 2015Trial
- Article
- Association between in-hospital antibiotic use and long-term outcomes in critically ill patients.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Navigating antibiotic therapy in acute cholangitis: Best practices and new insights.Journal of hepato-biliary-pancreatic sciences · 2025Review
- Antibiotics for Patients With a Planned Re-Laparotomy for Intra-Abdominal Infection.Surgical infections · 2024Observational
- Tailored Pre-Operative Antibiotic Prophylaxis to Prevent Post-Operative Surgical Site Infections in General Surgery.Antibiotics (Basel, Switzerland) · 2024Review
- Korean Guidelines for Use of Antibiotics for Intra-abdominal Infections in Adults.Infection & chemotherapy · 2022Review
- Article
- Short- versus long-course antibiotic therapy for sepsis: a post hoc analysis of the nationwide cohort study.Journal of intensive care · 2022Article
- WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections.World journal of emergency surgery : WJES · 2021Review
- Surgeon-led 7-VINCut Antibiotic Stewardship Intervention Decreases Duration of Treatment and Carbapenem Use in a General Surgery Service.Antibiotics (Basel, Switzerland) · 2020Article
- Antimicrobial therapy of 3 days or less is sufficient after successful ERCP for acute cholangitis.United European gastroenterology journal · 2020Article
- Use of Procalcitonin to Guide Discontinuation of Antimicrobial Therapy in Patients with Persistent Intra-Abdominal Collections: A Case Series.Case reports in infectious diseases · 2020Article
- Antimicrobial Prescribing Practices in Small Animal Emergency and Critical Care.Frontiers in veterinary science · 2020Article
- Is fixed short-course antimicrobial therapy justified for patients who are critically ill with intra-abdominal infections?Journal of the anus, rectum and colon · 2019Review
- Antibiotic duration can be shortened in postoperative intra-abdominal infection.Journal of thoracic disease · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe hypothesized that a longer duration of antibiotic treatment for intra-abdominal infections (IAI) would be associated with an increased risk of extra-abdominal infections (EAI) and high mortality.
methodsWe reviewed all IAI occurring in a single institution between 1997 and 2010. The IAI were divided into two groups consisting of those with a subsequent EAI and those without; the data for each group were analyzed. Patients with EAI following IAI were matched in a 1:2 ratio with patients who did not develop EAI on the basis of their Acute Physiology and Chronic Health Evaluation (APACHE II) score±1 point. Statistical analyses were done with the Student t-test, χ(2) analysis, Wilcoxon rank sum test, and multi-variable analysis.
resultsWe identified 2,552 IAI, of which 549 (21.5%) were followed by EAI. Those IAI that were followed by EAI were associated with a longer initial duration of antimicrobial therapy than were IAI without subsequent EAI (median 14 d [inter-quartile range (IQR) 10-22 d], vs. 10 d [IQR 6-15 d], respectively, p<0.01), a higher APACHE II score (16.6±0.3 vs. 11.2±0.2 points, p<0.01), and higher in-hospital mortality (17.1% vs. 5.4%, p<0.01). The rate of EAI following IAI in patients treated initially with antibiotics for 0-7 d was 13.3%, vs. 25.1% in patients treated initially for >7 d (p<0.01). A successful match was made of 469 patients with subsequent EAI to 938 patients without subsequent EAI, resulting in a mean APACHE II score of 15.2 for each group. After matching, IAI followed by EAI were associated with a longer duration of initial antimicrobial therapy than were IAI without subsequent EAI (median 14 d [9-22 d], vs. 11 d [7-16 d], respectively, p<0.01), and with a higher in-hospital mortality (14.9% vs. 9.0%, respectively, p<0.01). Logistic regression showed that days of antimicrobial therapy for IAI was an independent predictor of subsequent EAI (p<0.001).
conclusionsA longer duration of antibiotic therapy for IAI is associated with an increased risk of subsequent EAI and increased mortality.
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Registered trials
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