ArticleThe Plant cell2014
The Novel Nuclear Envelope Protein KAKU4 Modulates Nuclear Morphology in Arabidopsis.
Article in The Plant cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 114 citations in OpenAlex.
- Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function.Cytoskeleton (Hoboken, N.J.) · 2026Review
- A multiomics atlas of theScience advances · 2026Article
- The Pea Inner Nuclear Membrane SUN Domain Protein Modulates Plant (a)biotic Stress Responses by Regulating Nuclear Dynamics.Molecular plant pathology · 2025Article
- Dynamic changes in chromatin structure and transcriptional activity in the generative cells of Lilium longiflorum.Journal of plant research · 2025Article
- SCFScience advances · 2025Article
- Microfluidics to Follow Spatiotemporal Dynamics at the Nucleo-Cytoplasmic Interface During Plant Root Growth.Methods in molecular biology (Clifton, N.J.) · 2025Article
- CRWN nuclear lamina components maintain the H3K27me3 landscape and promote successful reproduction in Arabidopsis.The New phytologist · 2024Article
- Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome.BMC biology · 2024Article
- KAKU4 regulates leaf senescence through modulation of H3K27me3 deposition in the Arabidopsis genome.BMC plant biology · 2024Article
- Plant nuclear envelope as a hub connecting genome organization with regulation of gene expression.Nucleus (Austin, Tex.) · 2023Article
- Evolutionarily conserved protein motifs drive interactions between the plant nucleoskeleton and nuclear pores.The Plant cell · 2023Article
- CRWN nuclear lamina components maintain the H3K27me3 landscape and promote successful reproduction in Arabidopsis.bioRxiv : the preprint server for biology · 2023Article
- The nuclear lamina is required for proper development and nuclear shape distortion in tomato.Journal of experimental botany · 2023Article
- Symbiont-host interactome mapping reveals effector-targeted modulation of hormone networks and activation of growth promotion.Nature communications · 2023Article
- The plant nuclear lamina disassembles to regulate genome folding in stress conditions.Nature plants · 2023Article
- The large GTPase AtGBPL3 links nuclear envelope formation and morphogenesis to transcriptional repression.Nature plants · 2023Article
- Review
- Linking transcriptional silencing with chromatin remodeling, folding, and positioning in the nucleus.Current opinion in plant biology · 2022Review
- Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells.Protein & cell · 2022Article
- A glossary of plant cell structures: Current insights and future questions.The Plant cell · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In animals, the nuclear lamina is a fibrillar meshwork on the inner surface of the nuclear envelope, composed of coiled-coil lamin proteins and lamin binding membrane proteins. Plants also have a meshwork on the inner surface of the nuclear envelope, but little is known about its composition other than the presence of members of the CROWDED NUCLEI (CRWN) protein family, possible plant lamin analogs. Here, we describe a candidate lamina component, based on two Arabidopsis thaliana mutants (kaku2 and kaku4) with aberrant nuclear morphology. The responsible gene in kaku2 encodes CRWN1, and the responsible gene in kaku4 encodes a plant-specific protein of unknown function (KAKU4) that physically interacts with CRWN1 and its homolog CRWN4. Immunogold labeling revealed that KAKU4 localizes at the inner nuclear membrane. KAKU4 deforms the nuclear envelope in a dose-dependent manner, in association with nuclear membrane invagination and stack formation. The KAKU4-dependent nuclear envelope deformation was enhanced by overaccumulation of CRWN1, although KAKU4 can deform the nuclear envelope even in the absence of CRWN1 and/or CRWN4. Together, these results suggest that plants have evolved a unique lamina-like structure to modulate nuclear shape and size.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.