ArticleThe Analyst2014
Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein.
Article in The Analyst, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Substituent Effects of Fluorescein on Photoredox Initiating Performance under Visible Light.ACS omega · 2023Article
- Hybridization-based CpG methylation level detection using methyl-CpG-binding domain-fused luciferase.Analytical and bioanalytical chemistry · 2023Article
- Microfluidic epigenomic mapping technologies for precision medicine.Lab on a chip · 2019Review
- An examination of critical parameters in hybridization-based epigenotyping using magnetic microparticles.Biotechnology progress · 2018Article
- Engineering affinity agents for the detection of hemi-methylated CpG sites in DNA.Molecular systems design & engineering · 2016Article
- Characterization and directed evolution of a methyl-binding domain protein for high-sensitivity DNA methylation analysis.Protein engineering, design & selection : PEDS · 2015Article
- Label-free detection of missense mutations and methylation differences in the p53 gene using optically diffracting hydrogels.The Analyst · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Hypermethylation of CpG islands in gene promoter regions has been shown to be a predictive biomarker for certain diseases. Most current methods for methylation profiling are not well-suited for clinical analysis. Here, we report the development of an inexpensive device and an epigenotyping assay with a format conducive to multiplexed analysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.