Evidence map›Paper›PMID 24824361›Full record

ArticleJournal of pediatric gastroenterology and nutrition2014

Design and implementation of INSPPIRE.

Veronique D Morinville, Mark E Lowe, Monika Ahuja, Bradley Barth, Melena D Bellin, Heather Davis, Peter R Durie, Brian Finley, Douglas S Fishman, Steven D Freedman and 15 more

Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03672422 (Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer), which is not on this map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03672422 completednot on this mapstarted 2017, after this paper: background citation

Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) CPDPC16-03 Pediatric Longitudinal Cohort Study of Chronic Pancreatitis

Typeobservational_patient_registrySponsorAliye UcRan2017 to 2020Enrolled623ConditionsPancreatitis, Chronic, Pancreatitis, AcuteArmsBlood sample, Patient questionnaires, Saliva sample, Urine sample
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Article
  5. Diagnosis and Management of Acute Pancreatitis.Diagnostics (Basel, Switzerland) · 2025
    Review
  6. Observational
  7. Review of acute pancreatitis in children in India.Journal of family medicine and primary care · 2024
    Review
  8. Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2023
    Article
  9. Article
  10. Review
  11. Article
  12. An assessment of pancreatology education in North American pediatric gastroenterology fellowship programs.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Pediatric chronic pancreatitis without prior acute or acute recurrent pancreatitis: A report from the INSPPIRE consortium.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2020
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 16 institutions in 4 countries.

Veronique D Morinville*Montreal Children's Hospital, McGill University, Montreal, Canada †Children's Hospital of Pittsburgh, Pittsburgh, PA ‡University of Iowa Children's Hospital (UICH), Iowa City §University of Texas Southwestern Medical School, Dallas ||University of Minnesota, Amplatz Children's Hospital, Minneapolis ¶The Hospital for Sick Children and University of Toronto, Toronto, Canada #Baylor College of Medicine, Houston, TX **Beth Israel Deaconess Medical Center, Boston, MA ††Nationwide Children's Hospital (NCH), Columbus, OH ‡‡Seattle Children's Hospital, Seattle, WA §§University of California at San Francisco ||||University of New South Wales and Sydney Children's Hospital, Randwick, Australia ¶¶University of Utah, Salt Lake City ##Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Mark E Lowe
Monika Ahuja
Bradley Barth
Melena D Bellin
Heather Davis
Peter R Durie
Brian Finley
Douglas S Fishman
Steven D Freedman
Cheryl E Gariepy
Matthew J Giefer
Tanja Gonska
Melvin B Heyman
Ryan Himes
Sohail Husain
Soma Kumar
Chee Y Ooi
John F Pohl
Sarah Jane Schwarzenberg
David Troendle
Steven L Werlin
Michael Wilschanski
Elizabeth Yen
Aliye Uc
Boston Children's Hospital · USBaylor College of Medicine · USChildren's Hospital of Pittsburgh · USHadassah Medical Center · ILHospital for Sick Children · CANationwide Children's Hospital · USUniversity of California, San Francisco · USUniversity of Minnesota Children's Hospital · USBeth Israel Deaconess Medical Center · USMcGill University · CAPediatrics and Genetics · USSeattle Children's Hospital · USThe University of Texas Southwestern Medical Center · USUniversity of Iowa Stead Family Children’s Hospital · USUniversity of Utah · USUNSW Sydney · AU

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
University of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0M
Fatty Acid Defects & Oxidative Stress Modulate Islet Function in Cystic FibrosisR01DK097820 · NIDDK · UNIVERSITY OF IOWA · PI NORRIS, ANDREW W, UC, ALIYE · 2012 to 2016
$1.9M
Sitagliptin therapy to improve outcomes after islet autotransplantation.K23DK084315 · NIDDK · UNIVERSITY OF MINNESOTA · PI BELLIN, MELENA D. · 2010 to 2014
$816k
Characterization of Pancreatic Disease in a Novel Porcine Cystic Fibrosis ModelR01DK084049 · NIDDK · UNIVERSITY OF IOWA · PI UC, ALIYE · 2009 to 2010
$750k
INSPPIRE TO STUDY ACUTE RECURRENT AND CHRONIC PANCREATITIS IN CHILDRENR21DK096327 · NIDDK · UNIVERSITY OF IOWA · PI UC, ALIYE · 2012 to 2014
$586k
NCATS NIH HHS 2UL1 TR000442-06NCATS NIH HHS UL1 TR000114NCATS NIH HHS UL1 TR000442NIDDK NIH HHS DK096327NIDDK NIH HHS K23 DK084315NIDDK NIH HHS R01 DK084049NIDDK NIH HHS R01 DK097820NIDDK NIH HHS R21 DK096327
6 · The paper itself

Abstract

objectivesAcute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) are rare and poorly understood diseases in children. Better understanding of these disorders can only be accomplished via a multicenter, structured, data collection approach.

methodsThe International Study Group of Pediatric Pancreatitis: In Search for a Cure (INSPPIRE) consortium was created to investigate the epidemiology, etiologies, pathogenesis, natural history, and outcomes of pediatric ARP and CP. Patient and physician questionnaires were developed to capture information on demographics, medical history, family and social history, medications, hospitalizations, risk factors, diagnostic evaluation, treatments, and outcome information. Information collected in paper questionnaires was then transferred into Research Electronic Data Capture (REDCap), tabulated, and analyzed.

resultsThe administrative structure of the INSPPIRE consortium was established, and National Institutes of Health funding was obtained. A total of 14 sites (10 in the United States, 2 in Canada, and 2 overseas) participated. Questionnaires were amended and updated as necessary, followed by changes made into the REDCap database. Between September 1, 2012 and August 31, 2013, a total of 194 children were enrolled into the study: 54% were girls, 82% were non-Hispanic, and 72% were whites.

conclusionsThe INSPPIRE consortium demonstrates the feasibility of building a multicenter patient registry to study the rare pediatric diseases, ARP and CP. Analyses of collected data will provide a greater understanding of pediatric pancreatitis and create opportunities for therapeutic interventional studies that would not otherwise be possible without a multicenter approach.

Indexed as

PancreatitisRegistriesSurveys and QuestionnairesAdolescentBiomedical ResearchChildDatabase Management SystemsDatabases, FactualFemaleHumansInternational CooperationMalePancreatitis, ChronicRecurrenceResearch Design

Identifiers

PMID24824361
PMCPMC4141003
OpenAlexW2144841382

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.