Evidence map›Paper›PMID 24824288›Full record

Trial reportNutrients2014

Urinary metabolite profiles in premature infants show early postnatal metabolic adaptation and maturation.

Sissel J Moltu, Daniel Sachse, Elin W Blakstad, Kenneth Strømmen, Britt Nakstad, Astrid N Almaas, Ane C Westerberg, Arild Rønnestad, Kristin Brække, Marit B Veierød and 4 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Impact of Prematurity on Metabolic Maturation.Journal of proteome research · 2026
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  13. A LongitudinalMetabolites · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Sissel J MoltuDepartment of Pediatrics, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway. sissel.moltu@medisin.uio.no.
Daniel SachseDepartment of Medical Biochemistry, University of Oslo, P.O.Box 4950 Nydalen, Oslo 0424, Norway. sissel.moltu@medisin.uio.no.
Elin W BlakstadDepartment of Child and Adolescents Medicine, Akershus University Hospital, Lørenskog 1478, Norway. e.w.blakstad@medisin.uio.no.
Kenneth StrømmenDepartment of Nutrition, University of Oslo, P.O. Box 1046 Blindern, Oslo 0317, Norway. kestro@ous-hf.no.
Britt NakstadDepartment of Child and Adolescents Medicine, Akershus University Hospital, Lørenskog 1478, Norway. britt.nakstad@medisin.uio.no.
Astrid N AlmaasDepartment of Child and Adolescents Medicine, Akershus University Hospital, Lørenskog 1478, Norway. a.n.almaas@gmail.com.
Ane C WesterbergDepartment of Nutrition, University of Oslo, P.O. Box 1046 Blindern, Oslo 0317, Norway. a.c.westerberg@medisin.uio.no.
Arild RønnestadDepartment of Neonatal Intensive Care, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway. aronnest@ous-hf.no.
Kristin BrækkeDepartment of Neonatal Intensive Care, Oslo University Hospital, P.O. Box 4950 Nydalen, Oslo 0424, Norway. uxkbre@ous-hf.no.
Marit B VeierødDepartment of Nutrition, University of Oslo, P.O. Box 1046 Blindern, Oslo 0317, Norway. m.b.veierod@medisin.uio.no.
Per O IversenDepartment of Nutrition, University of Oslo, P.O. Box 1046 Blindern, Oslo 0317, Norway. p.o.iversen@medisin.uio.no.
Frode RiseDepartment of Chemistry, University of Oslo, P.O. Box 1033 Blindern, Oslo 0315, Norway. frode.rise@kjemi.uio.no.
Jens P BergDepartment of Medical Biochemistry, University of Oslo, P.O.Box 4950 Nydalen, Oslo 0424, Norway. j.p.berg@medisin.uio.no.
Christian A DrevonDepartment of Nutrition, University of Oslo, P.O. Box 1046 Blindern, Oslo 0317, Norway. c.a.drevon@medisin.uio.no.
University of Oslo · NOOslo University Hospital · NOAkershus University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEarly nutrition influences metabolic programming and long-term health. We explored the urinary metabolite profiles of 48 premature infants (birth weight < 1500 g) randomized to an enhanced or a standard diet during neonatal hospitalization.

methodsMetabolomics using nuclear magnetic resonance spectroscopy (NMR) was conducted on urine samples obtained during the first week of life and thereafter fortnightly.

resultsThe intervention group received significantly higher amounts of energy, protein, lipids, vitamin A, arachidonic acid and docosahexaenoic acid as compared to the control group. Enhanced nutrition did not appear to affect the urine profiles to an extent exceeding individual variation. However, in all infants the glucogenic amino acids glycine, threonine, hydroxyproline and tyrosine increased substantially during the early postnatal period, along with metabolites of the tricarboxylic acid cycle (succinate, oxoglutarate, fumarate and citrate). The metabolite changes correlated with postmenstrual age. Moreover, we observed elevated threonine and glycine levels in first-week urine samples of the small for gestational age (SGA; birth weight < 10th percentile for gestational age) as compared to the appropriate for gestational age infants.

conclusionThis first nutri-metabolomics study in premature infants demonstrates that the physiological adaptation during the fetal-postnatal transition as well as maturation influences metabolism during the breastfeeding period. Elevated glycine and threonine levels were found in the first week urine samples of the SGA infants and emerged as potential biomarkers of an altered metabolic phenotype.

Indexed as

Adaptation, PhysiologicalMetabolomeBiomarkersBreast FeedingFemaleGestational AgeHumansInfantInfant, PrematureInfant, Small for Gestational AgeMagnetic Resonance SpectroscopyMaleMetabolomicsNutrition AssessmentPrincipal Component AnalysisBiomarkers

Identifiers

PMID24824288
PMCPMC4042575
OpenAlexW2028416509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.