ArticleHeredity2014
On the definition and utilization of heritable variation among hosts in reproduction ratio R0 for infectious diseases.
Article in Heredity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Impact of genomic selection for disease resistance on the spread of infection in a simulated aquaculture population.Genetics, selection, evolution : GSE · 2026Article
- Estimation of Genetic Variance and Breeding Values for Infectious Disease Susceptibility From Simulated Longitudinal Data Using Generalized Linear Mixed Models Based on Transmission Dynamics.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Age-structured next generation matrix and RInfectious Disease Modelling · 2026Article
- Understanding the direct and indirect impacts of disease response phenotypes on chicken coccidiosis epidemiology: A modelling approach.PloS one · 2026Article
- SIRE 2.0: a novel method for estimating polygenic host effects underlying infectious disease transmission, and analytical expressions for prediction accuracies.Genetics, selection, evolution : GSE · 2025Article
- Experimental Infection Models and Their Usefulness for White Spot Syndrome Virus (WSSV) Research in Shrimp.Viruses · 2024Review
- Can breeders prevent pathogen adaptation when selecting for increased resistance to infectious diseases?Genetics, selection, evolution : GSE · 2022Article
- Why DoesFrontiers in immunology · 2022Review
- Why genetic selection to reduce the prevalence of infectious diseases is way more promising than currently believed.Genetics · 2021Article
- Estimating individuals' genetic and non-genetic effects underlying infectious disease transmission from temporal epidemic data.PLoS computational biology · 2020Article
- Genomic selection for white spot syndrome virus resistance in whiteleg shrimp boosts survival under an experimental challenge test.Scientific reports · 2020Article
- The Price equation as a bridge between animal breeding and evolutionary biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- The economic value of RGenetics, selection, evolution : GSE · 2020Article
- Prospects for the Analysis and Reduction of Damaging Behaviour in Group-Housed Livestock, With Application to Pig Breeding.Frontiers in genetics · 2020Review
- Genetic parameters and genomic breeding values for digital dermatitis in Holstein Friesian dairy cattle: host susceptibility, infectivity and the basic reproduction ratio.Genetics, selection, evolution : GSE · 2019Article
- Economic optimization of full-sib test group size and genotyping effort in a breeding program for Atlantic salmon.Genetics, selection, evolution : GSE · 2019Article
- Enhancing genetic disease control by selecting for lower host infectivity and susceptibility.Heredity · 2019Article
- Enhancing genetic disease control by selecting for lower host infectivity and susceptibility.Heredity · 2019Article
- Genetic differences in host infectivity affect disease spread and survival in epidemics.Scientific reports · 2019Article
- Derivation of the economic value of RGenetics, selection, evolution : GSE · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infectious diseases have a major role in evolution by natural selection and pose a worldwide concern in livestock. Understanding quantitative genetics of infectious diseases, therefore, is essential both for understanding the consequences of natural selection and for designing artificial selection schemes in agriculture. The basic reproduction ratio, R0, is the key parameter determining risk and severity of infectious diseases. Genetic improvement for control of infectious diseases in host populations should therefore aim at reducing R0. This requires definitions of breeding value and heritable variation for R0, and understanding of mechanisms determining response to selection. This is challenging, as R0 is an emergent trait arising from interactions among individuals in the population. Here we show how to define breeding value and heritable variation for R0 for genetically heterogeneous host populations. Furthermore, we identify mechanisms determining utilization of heritable variation for R0. Using indirect genetic effects, next-generation matrices and a SIR (Susceptible, Infected and Recovered) model, we show that an individual's breeding value for R0 is a function of its own allele frequencies for susceptibility and infectivity and of population average susceptibility and infectivity. When interacting individuals are unrelated, selection for individual disease status captures heritable variation in susceptibility only, yielding limited response in R0. With related individuals, however, there is a secondary selection process, which also captures heritable variation in infectivity and additional variation in susceptibility, yielding substantially greater response. This shows that genetic variation in susceptibility represents an indirect genetic effect. As a consequence, response in R0 increased substantially when interacting individuals were genetically related.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.