ArticleAIDS and behavior2014
Syringe exchange in the United States: a national level economic evaluation of hypothetical increases in investment.
Article in AIDS and behavior, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Return on investment of public health interventions: a systematic review.Journal of epidemiology and community health · 2017Pooled it
- Implications of Disruptions in HIV-Related Metrics.AIDS and behavior · 2026Article
- What We Owe: A Liberatory Ethics of Harm Reduction.Nursing inquiry · 2026Article
- Exploring Perspectives About Public Health Vending Machine Implementation on an American Indian Reservation in the Northern Midwest, United States.AIDS and behavior · 2026Article
- A comprehensive review of state laws that govern the distribution and possession of drug use equipment in the United States.The International journal on drug policy · 2026Review
- Tribally-affiliated syringe services programs in the United States: a brief report.Harm reduction journal · 2025Article
- Estimating the Cost-Saving Threshold of a Rural Syringe Services Program Before and During the COVID-19 Pandemic.AIDS and behavior · 2025Article
- NEXT: description, rationale, and evaluation of a novel internet-based mail-delivered syringe service program.Journal of substance use · 2024Article
- Implementation and first-year operating costs of an academic medical center-based syringe services program.Harm reduction journal · 2021Article
- Factors that influence enrollment in syringe services programs in rural areas: a qualitative study among program clients in Appalachian Kentucky.Harm reduction journal · 2021Article
- Expanding Mail-Based Distribution of Drug-Related Harm Reduction Supplies Amid COVID-19 and Beyond.American journal of public health · 2021Article
- Prevalence and correlates of receptive syringe-sharing among people who inject drugs in rural Appalachia.Addiction (Abingdon, England) · 2021Observational
- Guide for Future Directions for the Addiction and OUD Treatment Ecosystem.NAM perspectives · 2021Review
- Optimal Allocation of Societal HIV Prevention Resources to Reduce HIV Incidence in the United States.American journal of public health · 2021Article
- Cost-effectiveness of Direct Antiviral Agents for Hepatitis C Virus Infection and a Combined Intervention of Syringe Access and Medication-assisted Therapy for Opioid Use Disorders in an Injection Drug Use Population.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Implementation of Syringe Services Programs to Prevent Rapid Human Immunodeficiency Virus Transmission in Rural Counties in the United States: A Modeling Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Estimated effect of US state syringe sale policy on source of last-used injection equipment.The International journal on drug policy · 2020Article
- Cost-effectiveness of scaling-up HCV prevention and treatment in the United States for people who inject drugs.Addiction (Abingdon, England) · 2019Article
- Paraphernalia Laws, Criminalizing Possession and Distribution of Items Used to Consume Illicit Drugs, and Injection-Related Harm.American journal of public health · 2019Article
- Understanding the public health consequences of suspending a rural syringe services program: a qualitative study of the experiences of people who inject drugs.Harm reduction journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
To examine whether increasing investment in needle/syringe exchange programs (NSPs) in the US would be cost-effective for HIV prevention, we modeled HIV incidence in hypothetical cases with higher NSP syringe supply than current levels, and estimated number of infections averted, cost per infection averted, treatment costs saved, and financial return on investment. We modified Pinkerton's model, which was an adaptation of Kaplan's simplified needle circulation theory model, to compare different syringe supply levels, account for syringes from non-NSP sources, and reflect reduction in syringe sharing and contamination. With an annual $10 to $50 million funding increase, 194-816 HIV infections would be averted (cost per infection averted $51,601-$61,302). Contrasted with HIV treatment cost savings alone, the rate of financial return on investment would be 7.58-6.38. Main and sensitivity analyses strongly suggest that it would be cost-saving for the US to invest in syringe exchange expansion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.