ArticleMarine drugs2014
Actinomycetes from Red Sea sponges: sources for chemical and phylogenetic diversity.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Inhibitory Activity of Compounds Obtained fromPathogens (Basel, Switzerland) · 2025Article
- Exploring the diversity and antimicrobial potential of actinomycetes isolated from different environments in Saudi Arabia: a systematic review.Frontiers in microbiology · 2025Review
- Hyrtios sp.-associated Cladosporium sp. UR3 as a potential source of antiproliferative metabolites.BMC microbiology · 2024Article
- Targeting antimalarial metabolites from the actinomycetes associated with the Red Sea sponge Callyspongia siphonella using a metabolomic method.BMC microbiology · 2023Article
- Bioprospecting of unexplored halophilic actinobacteria against human infectious pathogens.3 Biotech · 2023Review
- Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential.FEMS microbes · 2023Article
- Metabolomic Profiling, In Vitro Antimalarial Investigation and In Silico Modeling of the Marine Actinobacterium StrainAntibiotics (Basel, Switzerland) · 2022Article
- ActinoBase: tools and protocols for researchers working onMicrobial genomics · 2022Article
- Pro-Apoptotic Activity of the Marine SpongeMarine drugs · 2022Article
- Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2022Article
- Diversity of endophytic bacteria of mulberry (Frontiers in microbiology · 2022Article
- Microbial diversity in Mediterranean sponges as revealed by metataxonomic analysis.Scientific reports · 2021Article
- Isolation, Phylogenetic and Gephyromycin Metabolites Characterization of New Exopolysaccharides-Bearing Antarctic Actinobacterium from Feces of Emperor Penguin.Marine drugs · 2021Article
- Existence in cellulose shelters: industrial and pharmaceutical leads of symbiotic actinobacteria from ascidian Phallusia nigra, Andaman Islands.World journal of microbiology & biotechnology · 2021Article
- Nocardia terrae sp. nov., an actinomycete isolated from soil in Thailand.Archives of microbiology · 2021Article
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- Actinomycetes from the Red Sea SpongeMicroorganisms · 2020Article
- Molecular Identification of SelectedInternational journal of environmental research and public health · 2019Article
- New bioactive metabolites from the elicited marine sponge-derived bacterium Actinokineospora spheciospongiae sp. nov.AMB Express · 2019Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diversity of actinomycetes associated with marine sponges collected off Fsar Reef (Saudi Arabia) was investigated in the present study. Forty-seven actinomycetes were cultivated and phylogenetically identified based on 16S rRNA gene sequencing and were assigned to 10 different actinomycete genera. Eight putatively novel species belonging to genera Kocuria, Mycobacterium, Nocardia, and Rhodococcus were identified based on sequence similarity values below 98.2% to other 16S rRNA gene sequences available in the NCBI database. PCR-based screening for biosynthetic genes including type I and type II polyketide synthases (PKS-I, PKS-II) as well as nonribosomal peptide synthetases (NRPS) showed that 20 actinomycete isolates encoded each at least one type of biosynthetic gene. The organic extracts of nine isolates displayed bioactivity against at least one of the test pathogens, which were Gram-positive and Gram-negative bacteria, fungi, human parasites, as well as in a West Nile Virus protease enzymatic assay. These results emphasize that marine sponges are a prolific resource for novel bioactive actinomycetes with potential for drug discovery.
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