ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2014
Behavioral and neural substrates of habit formation in rats intravenously self-administering nicotine.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
- Addiction spectrum disorder: a conceptual framework for comprehensive understanding of addictive disorders.Frontiers in psychology · 2026Article
- Outcome devaluation as a method for identifying goal-directed behaviors in rats.Nature protocols · 2025Review
- Sex differences in dorsal striatal volume and interest in quitting smoking.Drug and alcohol dependence · 2025Article
- Making and breaking habits: Revisiting the definitions and behavioral factors that influence habits in animals.Journal of the experimental analysis of behavior · 2024Review
- Subregion specific neuroadaptations in the female rat striatum during acute and protracted withdrawal from nicotine.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- On the interrelation between alcohol addiction-like behaviors in rats.Psychopharmacology · 2022Article
- Anhedonia in Nicotine Dependence.Current topics in behavioral neurosciences · 2022Review
- β2* nicotinic acetylcholine receptor subtypes mediate nicotine-induced enhancement of Pavlovian conditioned responding to an alcohol cue.Frontiers in behavioral neuroscience · 2022Article
- Dopamine Circuit Mechanisms of Addiction-Like Behaviors.Frontiers in neural circuits · 2021Review
- Fractionating the all-or-nothing definition of goal-directed and habitual decision-making.Journal of neuroscience research · 2020Review
- The transition to compulsion in addiction.Nature reviews. Neuroscience · 2020Review
- Addiction is driven by excessive goal-directed drug choice under negative affect: translational critique of habit and compulsion theory.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Goal-Directed and Habitual Control in Smokers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2020Article
- The neurobiology of addiction.Annals of the New York Academy of Sciences · 2019Article
- Heroin seeking becomes dependent on dorsal striatal dopaminergic mechanisms and can be decreased by N-acetylcysteine.The European journal of neuroscience · 2019Article
- Inflexible habitual decision-making during choice between cocaine and a nondrug alternative.Translational psychiatry · 2019Article
- Nicotine pre-treatment reduces sensitivity to the interoceptive stimulus effects of commonly abused drugs as assessed with taste conditioning paradigms.Drug and alcohol dependence · 2019Article
- Defining the place of habit in substance use disorders.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Behavioral and neural mechanisms underlying habitual and compulsive drug seeking.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Neurobiological Considerations for Tobacco Use Disorder.Current behavioral neuroscience reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tobacco addiction involves a transition from occasional, voluntary smoking towards habitual behavior that becomes increasingly resistant to quitting. The development of smoking habits may reflect a loss of behavioral control that can be modeled in rats. This study investigated the behavioral and neural substrates of habit formation in rats exposed to either brief (10 days) or extended (47 days) intravenous (IV) nicotine self-administration training. Following training, the first cohort of rats were exposed to a nicotine devaluation treatment, which involved repeated pairings of IV nicotine with lithium injection. They were then tested for sensitivity of responding to nicotine devaluation under extinction and reinstatement conditions. The second cohort of rats received equivalent self-administration training followed by processing of brain tissue for c-Fos immunohistochemistry. After brief training, devaluation suppressed nicotine-seeking during tests of extinction and reinstatement, confirming that responding is initially sensitive to current nicotine value, and therefore, goal directed. In contrast, after extended training, devaluation had no effect on extinction or reinstatement of responding, indicating that responding had become habitual. Complementary neuroanalysis revealed that extended nicotine self-administration was associated with increased c-Fos expression in brain regions implicated in habitual control of reward seeking, including activation of the dorsolateral striatum and substantia nigra pars compacta. These findings provide evidence of direct devaluation of an IV drug reward, that nicotine self-administration is initially goal-directed but becomes habitual with extended training, and that this behavioral transition involves activation of brain areas associated with the nigrostriatal system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.